PEDIATRIC BRAIN IMAGING

儿科脑成像

• 批准号: 7724332
• 负责人: Jay N. Giedd
• 金额: $ 0.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724332
• 关键词: Adolescent; Adult; Area; Attention deficit hyperactivity disorder; Behavioral; Brain; Brain imaging; Child; Childhood; Collection; Computer Retrieval of Information on Scientific Projects Database; Congenital adrenal hyperplasia; Data; Development; Disease; Dizygotic Twins; Funding; Genes; Genetic; Grant; Health; Hormones; Image; Institution; Klinefelter' s Syndrome; Literature; Magnetic Resonance Imaging; Maps; Mono-S; Nature; Neuropsychological Tests; Numbers; Pituitary-dependent Cushing' s disease; Precocious Puberty; Research; Research Design; Research Personnel; Resources; Schizophrenia; Seminal; Sex Characteristics; Shapes; Source; Structure; United States National Institutes of Health; Variant; Y Chromosome; brain behavior; brain size; neuroimaging; neuropsychiatry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driven by the hypothesis that many of the most severe neuropsychiatric disorders of childhood onset are manifestations of deviations from the path of normal brain development, the anatomical substrates of which can be detected by magnetic resonance imaging (MRI), our team has been acquiring and analyzing brain MRI scans from healthy and psychiatrically ill children, adolescents, and adults. The study design is longitudinal to assess not only brain size or shape differences but to map out the developmental curves for a variety of brain structures in health and in illness. Combining the brain imaging information with extensive behavioral and neuropsychological testing as well as genetic data allows us to explore the relationship between genes, brain, and behavior. Clinically, the project encompasses the largest imaging studies of ADHD and Childhood-Onset Schizophrenia. Seminal contributions to the literature have been produced in each of these areas. The normative development component utilizes the world's largest collection of well-characterized pediatric brain MRI scans (N = 1000) and serves as a resource for many neuroimaging projects throughout the world. To assess sex differences in the brain, we are examining subjects with variations in the number of X and Y chromosomes (i.e. Klinefelter Syndrome, XXXY) and subjects with hormone anomalies (i.e. Cushings disease, Congenital Adrenal Hyperplasia, Familial Precocious Puberty). To assess nature/nurture questions we are studying brain development in mono and dizygotic twins.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 儿童期发病的许多最严重的神经精神疾病都是偏离正常大脑发育路径的表现，其解剖学基础可以通过磁共振成像 (MRI) 检测到，这一假设的推动下，我们的团队一直在获取和分析健康和患有精神疾病的儿童、青少年和成人的大脑 MRI 扫描。该研究设计是纵向的，不仅可以评估大脑大小或形状差异，还可以绘制健康和疾病状态下各种大脑结构的发育曲线。将大脑成像信息与广泛的行为和神经心理学测试以及遗传数据相结合，使我们能够探索基因、大脑和行为之间的关系。在临床上，该项目涵盖了针对多动症和儿童期精神分裂症的最大规模的影像学研究。这些领域中的每一个领域都对文献做出了开创性的贡献。规范开发部分利用了世界上最大的特征明确的儿科脑部 MRI 扫描 (N = 1000) 集合，并作为世界各地许多神经影像项目的资源。为了评估大脑中的性别差异，我们正在检查 X 和 Y 染色体数量变异的受试者（即克氏综合症，XXXY）和激素异常的受试者（即库欣病、先天性肾上腺增生、家族性性早熟）。为了评估先天/后天问题，我们正在研究单卵双胞胎和异卵双胞胎的大脑发育。