BRAIN MRI & MAGNETIC RESONANCE SPECTROSCOPY IN TOURETTE SYNDROME

脑部核磁共振成像

• 批准号: 7724291
• 负责人: ROB NICOLSON
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724291
• 关键词: Adolescent; Basal Ganglia; Brain; Brain imaging; Child; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Corpus striatum structure; Data; Funding; Gilles de la Tourette syndrome; Grant; Gray unit of radiation dose; Head; Institution; Investigation; Knowledge; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; N-acetylaspartate; Neurobiology; Neurons; Numbers; Patients; Protons; Publishing; Research; Research Personnel; Resources; Scanning; Source; Techniques; Thalamic structure; United States National Institutes of Health; base; caudate nucleus; frontal lobe; gray matter; in vivo; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A number of volumetric and functional brain imaging studies suggest abnormalities in neuronal circuits involving the cortex, striatum, and thalamus as a possible cause of Tourette syndrome. Although the measurement of N-acetylaspartate (NAA), a neuronal marker, through proton magnetic resonance spectroscopy (MRS) provides a unique opportunity for the in vivo investigation of neuronal abnormalities in these regions, there have been, to date, no published studies of NAA or proton MRS in Tourette syndrome. However, pilot data from our initial MRS study of Tourette syndrome suggests neuronal abnormalities in the caudate nucleus and frontal lobes and a lack of the normal asymmetry seen in the caudate nucleus and frontal gray matter. The objective of the present study is to confirm and extend these findings in Tourette syndrome using magnetic resonance imaging and magnetic resonance spectroscopy. Children and adolescents with Tourette syndrome and a control group of children without tics or other major psychiatric illness will undergo magnetic resonance scanning on a 3 Tesla head only magnetic resonance scanner. Frontal gray and white matter volumes and the volume of the basal ganglia and the thalamus will be measured on magnetic resonance images using semiautomated techniques. The concentration of NAA will be measured in these regions as well using magnetic resonance spectroscopy. We hypothesize that patients will have reductions in frontal gray matter volumes and caudate nucleus volumes. Patients will also have abnormalities of NAA in these regions and will lack the normal asymmetry of the caudate nucleus, suggesting neuronal abnormalities. If these hypotheses are confirmed, these findings would further our knowledge of the neurobiological basis of Tourette syndrome and may ultimately be important in determining more effective treatments for tics.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 许多体积和功能脑成像研究表明，涉及皮质、纹状体和丘脑的神经元回路异常可能是多发性抽动症的原因之一。尽管通过质子磁共振波谱(MRS)对神经元标志物N-乙酰天冬氨酸(NAA)的测量为体内研究这些区域的神经元异常提供了独特的机会，但到目前为止，还没有关于NAA或质子MRS在Tourette综合征中的研究发表。然而，我们最初对多发性抽动症的MRS研究的试点数据表明，尾状核和额叶中的神经元异常，尾状核和额叶灰质中缺乏正常的不对称。本研究的目的是利用磁共振成像和磁共振波谱来证实和推广抽动症的这些发现。患有抽动症的儿童和青少年以及没有抽搐或其他重大精神疾病的对照组儿童将在3Tesla Head Only磁共振扫描仪上进行磁共振扫描。额叶灰质和白质体积以及基底节和丘脑的体积将使用半自动技术在磁共振图像上进行测量。这些区域的NAA浓度也将使用磁共振波谱进行测量。我们假设患者的额叶灰质体积和尾状核体积将会减少。患者还将在这些区域出现NAA异常，并缺乏正常的尾状核不对称，提示神经元异常。如果这些假说得到证实，这些发现将进一步加深我们对多发性抽动症的神经生物学基础的了解，并最终可能对确定更有效的抽搐治疗方法起到重要作用。