STYLOPEPTIDE 2, PROLINE-RICH CYCLODECAPEPTIDE FROM SPONGE STYLOTELLA SP

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of non-ribosomal cyclic peptides isolated from marine sources continues to grow. Such peptides are relatively stable toward enzymatic degradation and, with their less polar nature, are more biologically available than their linear cousins. Proline-rich cyclopeptides constitute a new class that has recently emerged. Most members of this group are sponge-derived hepta- or octapeptides with non-polar amino acid residues (usually with one or two aromatic representatives) interspersed among the prolines. Examples include the axinellins, axinastatins, hymenamides, phakellistatins, stylopeptide and wainunuamide. Phakellistatins are examples of proline-rich cyclic decapeptides. We have isolated and characterized a new proline-rich decapeptide, stylopeptide 2, obtained from the same collection of Stylotella sp. that provided stylopeptide and stylostatin.