COGNITIVE&NEURAL BASIS OF MEMORY IN OLDER AVIATORS GENETICALLY AT RISK FOR AD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 APOE？4等位基因是阿尔茨海默病(AD)的主要遗传风险因素。此外，超过25%的总人口是携带者。为了加强AD的早期识别，研究正在评估？4对老年非痴呆携带者记忆的影响。文献并不一致，很少有研究研究载脂蛋白对执行复杂的“现实世界”任务的老年专业人员的影响，比如驾驶飞机。我们最近对45名飞行员进行的结构性核磁共振研究发现，4名携带者在学习单词列表(Rey AVLT)时的记忆表现较差。有趣的是，没有观察到与海马体体积相关的差异。这项正在进行的功能磁共振研究旨在阐明在4名携带者中观察到的词汇表学习能力较差的神经机制。我们已经将Rey AVLT调整为用于功能磁共振成像的可视呈现格式。我们预测，在MTL区域(特别是海马区)、前额叶、顶叶和前扣带区的记忆编码过程中，4携带者总体上将比非携带者表现出更低的激活。我们还在测试空间导航记忆，因为导航在航空中至关重要。在这里，我们展示了一个由Shelton和Gabrieli(2002；2005)开发的测量和路线虚拟现实任务。我们将评估拥有高级FAA熟练程度评级的4家运营商在导航记忆编码(APOE X Experitative Interaction)期间显示保留激活的程度。这项研究招募了40名积极飞行、获得美国联邦航空局医学认证的飞行员，他们的熟练程度等级各不相同。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The APOE ¿4 allele is a major genetic risk factor Alzheimer's Disease (AD). Furthermore, over 25% of the general population are ¿4 carriers. To enhance early identification of AD, studies are assessing the impact of ¿4 on memory in older nondemented carriers. The literature is inconsistent and few studies have examined the impact of APOE ¿4 in older professionals performing complex "real-world" tasks, such as flying an airplane. Our recent structural MRI study of 45 aviators found that ¿4 carriers had poorer memory performance when learning a word list (Rey AVLT). Interestingly, no ¿4-related differences in hippocampal volume were observed. The fMRI study underway aims to shed light on the neural mechanisms associated with the poorer word list learning observed in ¿4 carriers. We have adapted the Rey AVLT to a visually presented format for fMRI. We predict that ¿4 carriers will show overall lower activation than non-carriers during memory encoding in MTL regions (specifically the hippocampus), prefrontal, parietal and anterior cingulate regions. We are also testing spatial navigational memory, as navigation is crucial in aviation. Here, we are presenting a survey and route virtual reality task developed by Shelton and Gabrieli (2002; 2005). We will assess the extent to which ¿4 carriers with advanced FAA proficiency ratings show preserved activation during navigational memory encoding (APOE x Expertise interaction). Forty actively flying, FAA medically certified aviators with a range of proficiency ratings are being recruited for the study.