COGNITIVE&NEURAL BASIS OF MEMORY IN OLDER AVIATORS GENETICALLY AT RISK FOR AD

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• 批准号: 7955363
• 负责人: JOY L TAYLOR
• 金额: $ 1.2万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955363
• 关键词: Alleles; Alzheimer' s Disease; Alzheimer' s disease risk; Anterior; Apolipoprotein E; Aviation; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Early identification; Flying body movement; Functional Magnetic Resonance Imaging; Funding; General Population; Grant; Hippocampus (Brain); Institution; Learning; Light; Literature; Magnetic Resonance Imaging; Memory; Parietal; Performance; Recruitment Activity; Research; Research Personnel; Resources; Route; Source; Surveys; Technology; Testing; United States National Institutes of Health; base; genetic risk factor; memory encoding; neuromechanism; relating to nervous system; virtual reality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The APOE ¿4 allele is a major genetic risk factor Alzheimer's Disease (AD). Furthermore, over 25% of the general population are ¿4 carriers. To enhance early identification of AD, studies are assessing the impact of ¿4 on memory in older nondemented carriers. The literature is inconsistent and few studies have examined the impact of APOE ¿4 in older professionals performing complex "real-world" tasks, such as flying an airplane. Our recent structural MRI study of 45 aviators found that ¿4 carriers had poorer memory performance when learning a word list (Rey AVLT). Interestingly, no ¿4-related differences in hippocampal volume were observed. The fMRI study underway aims to shed light on the neural mechanisms associated with the poorer word list learning observed in ¿4 carriers. We have adapted the Rey AVLT to a visually presented format for fMRI. We predict that ¿4 carriers will show overall lower activation than non-carriers during memory encoding in MTL regions (specifically the hippocampus), prefrontal, parietal and anterior cingulate regions. We are also testing spatial navigational memory, as navigation is crucial in aviation. Here, we are presenting a survey and route virtual reality task developed by Shelton and Gabrieli (2002; 2005). We will assess the extent to which ¿4 carriers with advanced FAA proficiency ratings show preserved activation during navigational memory encoding (APOE x Expertise interaction). Forty actively flying, FAA medically certified aviators with a range of proficiency ratings are being recruited for the study.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 APOE <$4等位基因是阿尔茨海默病（AD）的主要遗传危险因素。 此外，超过25%的总人口是携带者。 为了加强AD的早期识别，研究正在评估4对老年非痴呆症携带者记忆的影响。 文献是不一致的，很少有研究检查APOE 4在老年专业人员执行复杂的“现实世界”任务（如驾驶飞机）中的影响。 我们最近对45名飞行员进行的结构MRI研究发现，40名携带者在学习单词列表（Rey AVLT）时记忆力较差。 有趣的是，没有观察到海马体积的差异。正在进行的功能磁共振成像研究旨在阐明与在4名携带者中观察到的较差单词列表学习相关的神经机制。 我们已经适应了雷伊AVLT功能磁共振成像的视觉呈现格式。 我们预测，4携带者在MTL区域（特别是海马）、前额叶、顶叶和前扣带区域的记忆编码期间将显示比非携带者整体更低的激活。 我们也在测试空间导航记忆，因为导航在航空中至关重要。在这里，我们提出了一个调查和路线虚拟现实任务开发的谢尔顿和加布里埃利（2002年; 2005年）。 我们将评估4名具有高级FAA熟练度评级的携带者在导航记忆编码（APOE x专业知识相互作用）期间显示保留激活的程度。 40名积极飞行的FAA医学认证飞行员正在招募进行这项研究。