DISRUPTION OF RIGHT-LATERALIZED FRONTO-STRIATAL FUNCTIONAL CIRCUITRY IN FRAGI-X

FRAGI-X 中右外侧化额纹状体功能回路的破坏

• 批准号: 7722903
• 负责人: ELIZABETH WALTER
• 金额: $ 0.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722903
• 关键词: Brain; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Disruption; Fragile X Syndrome; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Head; Image; Institution; Left; Linear Models; Male Adolescents; Methods; Participant; Psychophysiology; Research; Research Personnel; Resources; Seeds; Series; Source; Testing; Time; United States National Institutes of Health; age group; frontal lobe; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Our lab (Hoeft et al, 2007) recently used fMRI to image participants with fragile X syndrome as they performed the Go/Nogo task. In contrast to the robust, right-lateralized fronto-striatal circuit active in typically developing participants during the Nogo portion of the task, we found reduced activation in this same circuit in the fragile X group. Specific Aims: In the present study, we wanted to assess whole-brain functional connectivity (psychophysiological interaction; PPI) analyses using the previously imaged group of 10 male adolescents with fragile X as well as 10 matched typically-developing controls and a third group of age-matched, developmentally-delayed control participants. The goal of this study was to determine whether the caudate specifically showed abnormal functional connectivity with the frontal cortex in participants with fragile X. Methods: To test this, we performed psychophysiological interaction (PPI) functional connectivity analyses using right and left caudate head and bodies as seed regions-of-interest (ROIs; right and left, ROI of interest and control ROI, respectively). Time-series were extracted from suprathreshold voxels within anatomically defined ROIs for each subject and were convolved with the effects of interest (Nogo vs. Go epochs), and used as regressors in the general linear model (GLM).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介： 我们的实验室（Hoeft et al，2007）最近使用fMRI对脆性X综合征的参与者进行Go/Nogo任务。在Nogo部分的任务中，与典型发育中的参与者活跃的右侧额-纹状体回路相反，我们发现脆性X组中同一回路的激活减少。 具体目标： 在本研究中，我们希望评估全脑功能连接（心理生理学相互作用; PPI）分析使用先前成像组的10名男性青少年脆性X，以及10个匹配的典型发展的控制和第三组年龄匹配，发展延迟的控制参与者。 这项研究的目的是确定在脆性X染色体的参与者中，尾状核是否特别显示出与额叶皮层的异常功能连接。 研究方法： 为了测试这一点，我们进行了心理生理相互作用（PPI）功能连接分析，使用右尾状核和左尾状核的头部和身体作为种子区域的利益（ROI;右和左，感兴趣的ROI和控制ROI，分别）。从解剖学定义的ROI内的阈上体素中提取每个受试者的时间序列，并与感兴趣的效应（Nogo与Go时期）进行卷积，并用作一般线性模型（GLM）中的回归量。