SPATIAL RESOLUTION DEPEND OF DTI TRACTOGRAPHY IN HUMAN OCCIPITO-CALLOSAL REGION

人体枕胼胝区 DTI 纤维成像的空间分辨率依赖

• 批准号: 7721364
• 负责人: DAE-SHIK KIM
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721364
• 关键词: Affect; Computer Retrieval of Information on Scientific Projects Database; Data; Dependence; Diffusion Magnetic Resonance Imaging; Fiber; Funding; Grant; Human; Institution; Invasive; Measures; Methods; Numbers; Research; Research Personnel; Resolution; Resources; Scheme; Seeds; Source; Structure; United States National Institutes of Health; Variant; Visual Fields; size; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spatial resolution dependence of DTI tractography in human occipito-callosal region Diffusion tensor imaging (DTI) and fiber tracking have been used to measure the fiber structural connectivity in humans in a non-invasive manner. However, low sensitivity is a principal limitation of these methods, causing a large number of possibly missing fiber tracts (FTs). Here we studied how the spatial resolution affects the sensitivity of the fiber tracing by rescaling data to different resolutions. Our data suggest that the spatial resolution can change the degree of the asymmetric cross-callosal connections in the lower visual field (loVF) compared to the upper visual field (upVF). Among connections from loVF, a larger voxel size resulted in a smaller number of FTs that was not commensurate to the number of seed points, while the number of connections from upVF was not significantly affected by variation in seeding point numbers. We conclude from our study that the spatial resolution of the acquired data will have to be taken into consideration in interpreting DTI fiber tracking data. Our results further suggest that the acquisition resolution of around 2 mm iso-voxel in the conventional DTI scheme can reconstruct the asymmetric upper and lower white matter structure in occipito-callosal region.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人体枕胼胝区 DTI 纤维束成像的空间分辨率依赖性 扩散张量成像（DTI）和纤维追踪已被用来以非侵入性方式测量人体的纤维结构连接性。然而，低灵敏度是这些方法的主要限制，导致大量可能丢失的纤维束（FT）。在这里，我们通过将数据重新缩放到不同的分辨率来研究空间分辨率如何影响光纤追踪的灵敏度。我们的数据表明，与上视野（upVF）相比，空间分辨率可以改变下视野（loVF）中不对称跨胼胝体连接的程度。在 loVF 的连接中，较大的体素大小导致 FT 数量较少，与种子点的数量不相称，而 upVF 的连接数量并未受到种子点数量变化的显着影响。我们从研究中得出结论，在解释 DTI 光纤跟踪数据时必须考虑所采集数据的空间分辨率。我们的结果进一步表明，传统 DTI 方案中约 2 mm 等体素的采集分辨率可以重建枕胼胝体区域不对称的上下白质结构。