SPATIAL RESOLUTION DEPEND OF DTI TRACTOGRAPHY IN HUMAN OCCIPITO-CALLOSAL REGION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人枕盖区弥散张量成像的空间分辨率相关性研究 扩散张量成像(DTI)和纤维跟踪已经被用来以非侵入性的方式测量人类的纤维结构连通性。然而，低灵敏度是这些方法的主要局限性，导致大量可能丢失的纤维束(FTs)。在这里，我们研究了空间分辨率如何通过将数据调整到不同的分辨率来影响光纤跟踪的灵敏度。我们的数据表明，与上视野(UpVF)相比，空间分辨率可以改变下视野(LoVF)内不对称的跨痂连接的程度。在来自loVF的连接中，较大的体素大小导致与种子点数量不相称的FT数量较少，而来自upVF的连接数量不受种子点数量变化的显著影响。我们的研究结论是，在解释DTI光纤跟踪数据时，必须考虑采集数据的空间分辨率。我们的结果进一步表明，在常规DTI方案中，采集分辨率约为2 mm的同体素可以重建枕-颧区不对称的上、下白质结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spatial resolution dependence of DTI tractography in human occipito-callosal region Diffusion tensor imaging (DTI) and fiber tracking have been used to measure the fiber structural connectivity in humans in a non-invasive manner. However, low sensitivity is a principal limitation of these methods, causing a large number of possibly missing fiber tracts (FTs). Here we studied how the spatial resolution affects the sensitivity of the fiber tracing by rescaling data to different resolutions. Our data suggest that the spatial resolution can change the degree of the asymmetric cross-callosal connections in the lower visual field (loVF) compared to the upper visual field (upVF). Among connections from loVF, a larger voxel size resulted in a smaller number of FTs that was not commensurate to the number of seed points, while the number of connections from upVF was not significantly affected by variation in seeding point numbers. We conclude from our study that the spatial resolution of the acquired data will have to be taken into consideration in interpreting DTI fiber tracking data. Our results further suggest that the acquisition resolution of around 2 mm iso-voxel in the conventional DTI scheme can reconstruct the asymmetric upper and lower white matter structure in occipito-callosal region.