SIMULTANEOUS MAPPING OF FUNCTIONAL MAPS & AXONAL CONNECTIVITY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ?OLD based functional MRI and Diffusion Tensor Imaging were performed in the same cat visual cortex, thus providing the map of the axonal circuitry underlying functional activation. Furthermore, the foci of fMRI activation were utilized as the seeding points for 3D DTI fiber reconstruction algorithms. From the study, it was observed that in vivo connectivity maps can be obtained in concordance with fMRI maps, thus greatly expanding the explanatory power of fMRI for cognitive neurosciences. The methods developed in this study will lay foundation for in vivo neuroanatomy and the ability of non-invasive longitudinal studies of brain development.