SIMULTANEOUS MAPPING OF FUNCTIONAL MAPS & AXONAL CONNECTIVITY

功能图的同步绘制

• 批准号: 7420421
• 负责人: DAE-SHIK KIM
• 金额: $ 2.09万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420421
• 关键词: brain; cats; diffusion magnetic resonance imaging; functional magnetic resonance imaging; neuroanatomy; visual cortex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ?OLD based functional MRI and Diffusion Tensor Imaging were performed in the same cat visual cortex, thus providing the map of the axonal circuitry underlying functional activation. Furthermore, the foci of fMRI activation were utilized as the seeding points for 3D DTI fiber reconstruction algorithms. From the study, it was observed that in vivo connectivity maps can be obtained in concordance with fMRI maps, thus greatly expanding the explanatory power of fMRI for cognitive neurosciences. The methods developed in this study will lay foundation for in vivo neuroanatomy and the ability of non-invasive longitudinal studies of brain development.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。?基于OLD的功能性MRI和扩散张量成像在同一只猫的视皮层中进行，从而提供了功能激活下的轴突回路图。此外，fMRI激活的病灶被用作3D DTI纤维重建算法的种子点。从这项研究中，可以观察到，在体内的连接图可以获得一致的功能磁共振成像地图，从而大大扩展了功能磁共振成像的解释能力的认知神经科学。本研究所建立的方法将为在体神经解剖学和脑发育的无创纵向研究奠定基础。