DRUG DISCOVERY FOR GAUCHER'S DISEASE

戈谢氏病的药物发现

• 批准号: 7722381
• 负责人: Jennifer Kelley
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722381
• 关键词: Chemicals; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Drug effect disorder; Enzymes; Funding; Gaucher Disease; Grant; Institution; Molecular Chaperones; National Cancer Institute; Neuropathy; Research; Research Personnel; Resources; Source; United States National Institutes of Health; beta Glucosidases; beta-Glucosidase; drug discovery; mutant; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has used AutoDock in a virtual screen of the National Cancer Institute Diversity data against the Beta-glucosidase mutant enzyme that is found in people suffering Gaucher Disease, a lysosomal storage disorder causing severe neuropathy. The action of drugs on this mutant is to act as a "chemical chaperone" to assist in the proper folding of the functioning enzyme.

这个子项目是众多研究子项目之一