DRUG DISCOVERY FOR GAUCHER'S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目在国家癌症研究所多样性数据的虚拟屏幕上使用AutoDock来对抗在患有高谢病的人中发现的β-葡萄糖苷酶突变酶。高谢病是一种溶酶体储存障碍，会导致严重的神经疾病。药物对这个突变体的作用是充当一个“化学伴侣”，帮助正常工作的酶正确折叠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has used AutoDock in a virtual screen of the National Cancer Institute Diversity data against the Beta-glucosidase mutant enzyme that is found in people suffering Gaucher Disease, a lysosomal storage disorder causing severe neuropathy. The action of drugs on this mutant is to act as a "chemical chaperone" to assist in the proper folding of the functioning enzyme.