DRUG DISCOVERY FOR GAUCHER'S DISEASE
DRUG DISCOVERY FOR GAUCHER'S DISEASE
批准号:
7955273
负责人:
Jennifer Kelley
金额:
$0.32万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-05-01 至 2010-04-30
关键词:
Biomedical ComputingChemicalsComputer Retrieval of Information on Scientific Projects DatabaseDataDiseaseDrug effect disorderEnzymesFundingGaucher DiseaseGrantInstitutionMolecular ChaperonesNational Cancer InstituteNeuropathyResearchResearch PersonnelResourcesSourceUnited States National Institutes of Healthbeta Glucosidasesbeta-Glucosidasedrug discoverymutantvirtual
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
该项目在国家癌症研究所多样性数据的虚拟屏幕上使用AutoDock来对抗在患有高谢病的人中发现的β-葡萄糖苷酶突变酶。高谢病是一种溶酶体储存障碍,会导致严重的神经疾病。药物对这个突变体的作用是充当一个“化学伴侣”,帮助正常工作的酶正确折叠。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This project has used AutoDock in a virtual screen of the National Cancer Institute Diversity data against the Beta-glucosidase mutant enzyme that is found in people suffering Gaucher Disease, a lysosomal storage disorder causing severe neuropathy. The action of drugs on this mutant is to act as a "chemical chaperone" to assist in the proper folding of the functioning enzyme.
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DRUG DISCOVERY FOR GAUCHER'S DISEASE
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批准号:8169354
-
项目类别:
-
资助金额:$3.35万
-
财政年份:2010
-
负责人:Jennifer Kelley
-
依托单位:
DRUG DISCOVERY FOR GAUCHER'S DISEASE
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批准号:7722381
-
项目类别:
-
资助金额:$0.32万
-
财政年份:2008
-
负责人:Jennifer Kelley
-
依托单位:
DRUG DISCOVERY FOR GAUCHER'S DISEASE
-
批准号:7601728
-
项目类别:
-
资助金额:$0.18万
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财政年份:2007
-
负责人:Jennifer Kelley
-
依托单位:
海外基金