课题基金 / 基金详情

X-RAY INTERFERENCE STUDIES OF TROPONIN MOVEMENTS DURING MUSCLE ACTIVATION

X-RAY INTERFERENCE STUDIES OF TROPONIN MOVEMENTS DURING MUSCLE ACTIVATION
肌肉激活过程中肌钙蛋白运动的 X 射线干扰研究
批准号:
7722777
负责人:
HUGH HUXLEY
金额:
$1.9万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-04-01 至 2008-12-31

项目摘要

项目成果

HUGH HUXLEY的其他基金

相似基金

相关文献

中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vertebrate skeletal muscle is switched on by the action of calcium ions binding to the regulatory protein troponin, part of a complex in the actin-containing filaments that actively slide past the myosin filaments during contraction. This binding alters the position of the second regulatory protein tropomyosin, which controls access of the myosin crossbridges to the underlying actin filaments, allowing tension development. It is well-established that tropomyosin changes its azimuthal position on actin during activation, but how this is brought about is at present unknown. The high-resolution crystallographic structure of troponin has been solved recently, suggesting that part of that structure could undergo a tilting movement to move tropomyosin. This might show up as small changes in the axial position of the center of mass of troponin that could be measured by studying the interference fine structure of the 385A meridional reflections from the axial repeat of troponin along actin filaments. This fine structure is generated by symmetrical positioning of actin filaments on either side of the Z-lines, and changes in such fine structure enable one to measure changes in axial position with sub-nanometer accuracy. We have already had considerable successful experience in applying this technique to measurements of the detailed behavior of myosin crossbridges during muscle contraction (see attached publications). We now need considerably more data, to obtain a convincing picture of the phenomenon and to study it in a time-resolved manner, so as to correlate the changes
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
X-RAY INTERFERENCE STUDIES OF TROPONIN MOVEMENTS DURING MUSCLE ACTIVATION
STRUCTURAL STUDIES OF MUSCLE TRANSIENTS
  • 批准号:
    6316845
  • 项目类别:
  • 资助金额:
    $8.93万
  • 财政年份:
    1999
  • 负责人:
    HUGH HUXLEY
  • 依托单位:
    --
STRUCTURAL STUDIES OF MUSCLE TRANSIENTS
  • 批准号:
    6315738
  • 项目类别:
  • 资助金额:
    $8.93万
  • 财政年份:
    1999
  • 负责人:
    HUGH HUXLEY
  • 依托单位:
    --
BIOCAT BEAMLINE TEST EXPERIMENTS
国内基金
海外基金
greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
  • 批准号:
    --
  • 项目类别:
    外国学者研究基金项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    YU BYUNGJUN
  • 依托单位:
Incentive and governance schenism study of corporate green washing behavior in China: Based on an integiated view of econfiguration of environmental authority and decoupling logic
  • 批准号:
    --
  • 项目类别:
    外国学者研究基金项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    YU BYUNGJUN
  • 依托单位: