课题基金 / 基金详情

X-RAY STUDIES OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE BRAIN TISSUE

X-RAY STUDIES OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE BRAIN TISSUE
阿尔茨海默病脑组织中神经原纤维缠结的 X 射线研究
批准号:
7722765
负责人:
Sarah E. Rice
金额:
$2.12万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-04-01 至 2008-12-31

项目摘要

项目成果

Sarah E. Rice的其他基金

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The visible neuronal pathology that occurs in Alzheimer's disease (AD) and a number of other dementia-causing diseases is composed of a polymerized form of the microtubule-binding protein, tau. Collectively, these diseases are termed "tauopathies" and represent the predominant cause of human dementia. This pathology occurs when tau, a molecule that possesses little ordered structure in solution, polymerizes into an apparently well-ordered filament. Tau filaments can take on "straight" (single) or paired helical forms. This self-assembly phenomenon is of interest in its own right as a biophysical process, but this interest is made more acute by the potential relevance of its mechanism to a large number of human neurodegenerative disorders. Similar to the tauopathies (AD, Pick disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), FTDP-17 dementias, and others)(Lee, V., et al Ann. Rev. Neurosci. 24:1121-1159, 2001), aggregation of other proteins by demonstrably similar mechanisms is a characteristic of several other neurodegenerative diseases. Thus, understanding how and why tau polymerizes could open avenues for the development not only of therapeutic agents directed at AD, but at compounds to treat the broader base of neurodegenerative diseases.. Preliminary data taken at Bio-CAT identified diffraction patterns seen previously in purified NFTs, and also identified a number of new structural features, as well as a correspondence between tissue morphology and NFT orientation.
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Src kinase phosphoregulation of the human mitotic kinesin, Eg5
Src kinase phosphoregulation of the human mitotic kinesin, Eg5
SAXS STUDY OF REGULATION OF THE KINESIN-1 MOTOR BY THE KINESIN LIGHT CHAINS
  • 批准号:
    8168626
  • 项目类别:
  • 资助金额:
    $0.54万
  • 财政年份:
    2010
  • 负责人:
    Sarah E. Rice
  • 依托单位:
SAXS STUDY OF REGULATION OF THE KINESIN-1 MOTOR BY THE KINESIN LIGHT CHAINS
  • 批准号:
    7954910
  • 项目类别:
  • 资助金额:
    $0.65万
  • 财政年份:
    2009
  • 负责人:
    Sarah E. Rice
  • 依托单位: