Procedures to Assess the Hazards of a Superfund Site

德克萨斯A & M大学拟议的超级基金基础研究计划（SBRP）将利用 综合研究模式，以调查潜在的不利生态和人类健康的影响， 建立化学品和混合物超级基金，以改进风险评估模式。的主要目标 该计划是进行基础研究，以减少与风险评估相关的不确定性， 这有助于提高科学界和公众对总体风险评估进程的信心。 我们假设，由于暴露于 超基金相关的化学混合物是多因素的，与个体之间的相互作用有关。 化学品及其处置，以及目标生物受体及其遗传 敏感性拟议的研究包括三个基于机制的研究项目，重点是 通过内分泌干扰、遗传毒性和细胞损伤发挥作用的超级基金毒物。项目4将 调查化学品引起出生缺陷的遗传易感性和易感性。的发展 项目5将采用新的污染介质修复方法。人力和 生态系统暴露和风险评估研究将在项目6中进行调查。第7章调查 基因-环境相互作用影响出生缺陷的风险。七个独立项目的研究 将由图像分析，分析，实地研究，行政和培训核心支持。的 该计划还包括一个研究翻译核心，将扩大与区域 美国环境保护局的现场管理人员，以促进生物 在超级基金的地点进行风险评估。一个外联核心将交流研究成果 社区团体和学生的成果。

The proposed Superfund Basic Research Program (SBRP) at Texas A&M University will utilize an integrated research model to investigate the potential adverse ecological and human health effects of Superfund chemicals and mixtures to improve the risk assessment paradigm. The major objective of the program is to conduct fundamental research to reduce the uncertainty associated with risk assessment of complex mixtures, and to improve scientific and public confidence in the overall risk assessment process. We hypothesize that adverse environmental and human health effects resulting from exposure to Superfund-related chemical mixtures are multi-factorial and associated with interactions of individual chemicals and their disposition, as well as exposure of target biological receptors and their genetic sensitivities. The proposed studies include three mechanism-based research projects focused on Superfund toxicants that act through endocrine disruption, genotoxicity and cellular injury. Project 4 will investigate genetic susceptibility and predisposition to chemical-induced birth defects. The development of novel methods for remediation of contaminated media will be carried out in Project 5. Human and ecosystem exposure and risk assessment studies will be investigated in Project 6. Project 7 will investigate gene-environment interactions affecting the risk of birth defects. Research in the seven individual projects will be supported by the Image Analysis, Analytical, Field Studies, Administrative, and Training Cores. The program also includes a Research Translation Core that will expand ongoing collaborations with Regional Site Managers at the United States Environmental Protection Agency to facilitate incorporation of biological test protocols into risk assessment at Superfund sites. An Outreach Core will communicate research results to community groups and students.