Development of functional dendrimer-like inorganic nanomaterials with hierarchical pores for biological applications

开发用于生物应用的具有分级孔的功能性树枝状大分子无机纳米材料

• 批准号: DP140104062
• 负责人: Prof Shizhang Qiao
• 金额: $ 65.02万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-04-29 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104062
• 关键词: Development; functional; dendrimer; like; inorganic

This project aims to engineer a series of brand new dendrimer-like mesoporous silica nanoparticles with hierarchical pore structure and favourable surface functionality as nanocarriers to construct a smart delivery system. Unique materials structure and surface functionalisation design can endow the system with advanced characteristics of the co-loading of different therapeutic agents and the highly efficient target delivery that are not readily obtainable using other organic or inorganic materials. The proposed delivery systems are of great importance for improving the therapeutic efficiency of complex diseases, and in general, for expanding human’s life span.

该项目旨在设计一系列全新的树状分子状介孔二氧化硅纳米粒子，具有分级孔结构和良好的表面功能作为纳米载体，以构建智能递送系统。独特的材料结构和表面功能化设计可以赋予系统不同治疗剂的共负载和高效靶向递送的先进特性，这些特性是使用其他有机或无机材料不容易获得的。这些给药系统对于提高复杂疾病的治疗效率和延长人类寿命具有重要意义。