MECHANISTIC ELUCIDATION USING SINGLE MOLECULE MICROSCOPY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studying floresecence spectrum & fluoresence quenching with metals of fluoresecent probes. Studying the mechanism of several known organometallic reactions to determine mechanism (kinetics, binding order, etc.) of the reaction. With a better understanding of the mechanism these metal catalyzed reactions can be improved to optimize these catalysts commonly used in organicsynthesis. Study is utilizing the techniques of TIRF microscopy to study the reactions and custom synthesized fluorescent probes developed in our laboratory.