MECHANISTIC ELUCIDATION USING SINGLE MOLECULE MICROSCOPY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 研究了荧光探针的荧光光谱及其与金属的荧光猝灭。研究已知的几种有机金属反应的机理，以确定机理(动力学、结合顺序等)。反应的结果。使用 更好地了解这些金属催化反应的机理，可以改进和优化这些有机合成中常用的催化剂。研究是利用TIRF显微镜技术来研究 这些反应和定制合成的荧光探针是在我们实验室开发的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studying floresecence spectrum & fluoresence quenching with metals of fluoresecent probes. Studying the mechanism of several known organometallic reactions to determine mechanism (kinetics, binding order, etc.) of the reaction. With a better understanding of the mechanism these metal catalyzed reactions can be improved to optimize these catalysts commonly used in organicsynthesis. Study is utilizing the techniques of TIRF microscopy to study the reactions and custom synthesized fluorescent probes developed in our laboratory.