MECHANISTIC ELUCIDATION USING SINGLE MOLECULE MICROSCOPY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 荧光光谱及金属荧光探针的荧光猝灭研究。研究几种已知的有机金属反应的机理，以确定机理（动力学，结合顺序等）的反应。与 更好地理解这些金属催化反应的机理可以改进以优化这些在有机合成中常用的催化剂。研究利用TIRF显微镜技术来研究 我们实验室开发的反应和定制合成的荧光探针。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studying floresecence spectrum & fluoresence quenching with metals of fluoresecent probes. Studying the mechanism of several known organometallic reactions to determine mechanism (kinetics, binding order, etc.) of the reaction. With a better understanding of the mechanism these metal catalyzed reactions can be improved to optimize these catalysts commonly used in organicsynthesis. Study is utilizing the techniques of TIRF microscopy to study the reactions and custom synthesized fluorescent probes developed in our laboratory.