DIFFUSION CORRECTED RECONSTRUCTIONS OF PARTIAL PRESSURE OF OXYGEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肺氧分压（pO 2）和氧耗率（R）是两个重要的 肺功能参数。超极化氦-3（HP_3 He）T_1与 局部氧浓度为高分辨率区域制图提供了基础 肺内pO 2和R的分布。尽管氧敏HP 3 He MRI技术 已应用于人类受试者和几种动物，再现性研究 文献中很少报道。本工作提出了一个初步的重复性研究猪 模型在这项研究中，重要的扫描参数，如测量定时和翻转角， 优化以最小化噪声引起的测量不确定性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulmonary partial pressure of oxygen (pO2) and oxygen depletion rate (R) are two important parameters of lung function. The dependence of hyperpolarized helium-3 (HP 3He) T1 on local oxygen concentration provides the basis for high-resolution mapping of the regional distributions of pO2 and R in the lung. Although the oxygen-sensitive HP 3He MRI technique has been applied in human subjects and several animal species, reproducibility studies are rarely reported in the literature. This work presents a preliminary reproducibility study on a pig model. In this study, important scan parameters, such as measurement timing and flip angle, are optimized to minimize the noise-induced measurement uncertainty.