HIGH RESOLUTION MEASUREMENT OF REGIONAL ALVEOLAR PARTIAL PRESSURE OF OXYGEN

高分辨率测量区域肺泡氧分压

• 批准号: 7723835
• 负责人: Warren Bruce Gefter
• 金额: $ 2.18万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723835
• 关键词: Address; Alveolar; Animals; Computer Retrieval of Information on Scientific Projects Database; Disease model; Environmental air flow; Funding; Gases; Grant; Human; Institution; Invasive; Lung; Lung diseases; Magnetic Resonance Imaging; Measurement; Monitor; Mus; Oxygen; Partial Pressure; Physiology; Reproducibility; Research; Research Personnel; Resolution; Resources; Respiratory physiology; Source; Structure; Techniques; Therapeutic Intervention; United States National Institutes of Health; interest; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Non-invasive, regional assessment of lung function has the potential to markedly enhance the monitoring of progression of pulmonary diseases, as well as quantitative assessment of response to therapeutic intervention. Over the last decade, quantitative Hyperpolarized (HP) 3He MRI techniques have been developed to address crucial aspects of both lung structure and function. Alveolar partial pressure of oxygen is one of the important pulmonary markers with high sensitivity to alterations of regional lung physiology. The majority of currently existing PAO2 measurement techniques using polarized gas MRI are tailored towards large animals and humans which are impractical in mice. Ability to perform these measurements with high accuracy in mice, apart from availability of numerous interesting disease models, enables us to tailor ventilation parameters under full control and repeat measurements with an unprecedented reproducibility level that is difficult or impossible in larger species.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 肺功能的非侵入性区域评估有可能显着增强 监测肺部疾病的进展，以及定量评估 对治疗干预的反应。在过去的十年中，定量超极化（HP）3HE 已经开发了MRI技术来解决肺结构和功能的关键方面。 氧气的肺泡部分压是具有高灵敏度的重要肺标记之一 改变区域肺生理学。当前现有的PAO2测量大多数 使用偏振气MRI的技术针对大型动物和人类量身定制 小鼠不切实际。 除了小鼠的能力以高精度执行这些测量 众多有趣的疾病模型的可用性，使我们能够在下面量身定制通风参数 完全控制和重复测量，具有前所未有的可重复性水平，这很困难或 在较大的物种中不可能。