FULLERENE

富勒烯

• 批准号: 7721155
• 负责人: GRAEME S WILSON
• 金额: $ 1.62万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721155
• 关键词: Affect; Behavior; Cells; Chemical Warfare; Computer Retrieval of Information on Scientific Projects Database; Condition; Contrast Media; Cultured Cells; Encapsulated; Fullerenes; Funding; Grant; Human; Institution; Ionic Strengths; Ions; Magnetic Resonance Imaging; Metals; Mus; Object Attachment; Physiological; Property; Protons; Research; Research Personnel; Resources; Serum; Serum Albumin; Source; United States National Institutes of Health; Water; base; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Water-soluble derivatives of endohedral metallofullerenes possess unique potential for medicinal applications since the fullerene cage protects the encapsulated metal ion from external chemical attack and metal ion release in the body. Derivatized water-soluble Gd-based metallofullerenes are excellent MRI contrast agents with unusually large proton relaxivities for agents with no direct Gd-OH2 bonding. Phantom and in vivo MRI studies have both shown promising results 1) Study the affect of ionic strength on the aggregation properties of these water-soluble gadofulllerenes. 2) Study the effect of Human Serum Albumin (HSA) and mice serum on the aggregation properties of the gadofullerenes under physiological conditions. 3) Follow the aggregation behaviour of the gadofullerenes in cell cultures and check for the accumulation inside cells, thereby exploring the potential of gadofullerenes as the first intracellular MRI contrast agents.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 内嵌金属富勒烯的水溶性衍生物具有独特的医药应用潜力，因为富勒烯笼保护包封的金属离子免受外部化学攻击和金属离子在体内释放。衍生的水溶性Gd基金属富勒烯是优异的MRI造影剂，对于没有直接Gd-OH 2键合的试剂具有异常大的质子弛豫率。体模和体内MRI研究都显示出有希望的结果 1)研究离子强度对这些水溶性钆富勒烯聚集特性的影响。 2)研究了生理条件下人血清白蛋白（HSA）和小鼠血清对钆富勒烯聚集特性的影响。 3)跟踪钆富勒烯在细胞培养物中的聚集行为，并检查细胞内的积累，从而探索钆富勒烯作为第一种细胞内MRI造影剂的潜力。