MECHANISMS OF BIOORGANIC AND ORGANOMETALLIC CYCLIZATION REACTIONS

生物有机和有机金属环化反应的机制

• 批准号: 7723163
• 负责人: Dean Tantillo
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723163
• 关键词: Anabolism; Award; Biological Factors; Cations; Chemicals; Complex; Computer Retrieval of Information on Scientific Projects Database; Cyclization; DNA Sequence Rearrangement; Funding; Grant; Institution; Methods; Molecular; Organic Chemicals; Reaction; Research; Research Personnel; Resources; Source; Terpenes; Transition Elements; United States National Institutes of Health; chemical reaction; quantum

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of the research proposed herein, a renewal of CHE030089N, is to apply modern quantum chemical methods to the elucidation of molecular mechanisms of organic chemical reactions that are used in the synthesis and biosynthesis of polycyclic organic molecules. During this award period, we will concentrate on three subprojects: (project 1; continued from the previous grant period) cation-promoted polycyclization reactions involved in biosyntheses of terpene natural products, (project 2; expanded from the related project from the previous grant period) pericyclic cascade reactions used in the synthesis of complex cyclic molecules, and (project 3; expanded from the related project from the previous grant period) transition metal promoted sigmatropic rearrangements.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本文提出的CHE030089N的研究重点是应用现代量子化学方法来阐明用于多环有机分子合成和生物合成的有机化学反应的分子机理。在本授权期内，我们将集中于三个子项目：(项目1；延续于上一授予期)涉及萜类天然产物生物合成的阳离子促进的多环化反应；(项目2，由上一授予期的相关项目扩展而来)用于合成复杂环状分子的周环级联反应；以及(项目3，由上一授予期的相关项目扩展而来)过渡金属促进的S型重排。