MECHANISMS OF BIOORGANIC AND ORGANOMETALLIC CYCLIZATION REACTIONS

生物有机和有机金属环化反应的机制

• 批准号: 8171768
• 负责人: Dean Tantillo
• 金额: $ 0.15万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171768
• 关键词: Anabolism; Award; Biological Factors; Cations; Chemicals; Complex; Computer Retrieval of Information on Scientific Projects Database; Cyclization; Funding; Grant; Institution; Methods; Molecular; Organic Chemicals; Reaction; Research; Research Personnel; Resources; Source; Terpenes; United States National Institutes of Health; chemical reaction; quantum

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of the research proposed herein, a renewal of CHE030089N, is to apply modern quantum chemical methods to the elucidation of molecular mechanisms of organic chemical reactions that are used in the synthesis and biosynthesis of polycyclic organic molecules. During this award period, we will concentrate on the two subprojects shown in Figure 1: project 1 (continued from the previous grant period) cation-promoted polycyclization reactions involved in biosyntheses of terpene natural products; project 2 (continued from the related project from the previous grant period) pericyclic reactions used in the synthesis of complex cyclic molecules.

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