FAMILY INVESTIGATION OF NEPHROPATHY AND DIABETES (FIND)

肾病和糖尿病的家庭调查（查找）

• 批准号: 7723452
• 负责人: SUDHA K IYENGAR
• 金额: $ 0.91万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723452
• 关键词: Admixture; African American; American; American Indians; Archives; B-Lymphocytes; Biochemical; Biological; Biological Assay; Blood specimen; Case-Control Studies; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Databases; Diabetes Mellitus; Diabetic Nephropathy; Diabetic Retinopathy; Eligibility Determination; End stage renal failure; Enrollment; European; Family; Family Study; Funding; Future; Genes; Genetic; Genome; Genome Scan; Goals; Grant; Institution; Investigation; Journals; Kidney Diseases; Kidney Failure; Lead; Linkage Disequilibrium; Localized; Manuscripts; Maps; Medical; Medical Records; Mexican Americans; Participant; Patient Self-Report; Phase; Plasma; Population; Predisposition; Preparation; Prevention; Questionnaires; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Secure; Source; United States National Institutes of Health; Urine; case control; genetic analysis; genetic linkage analysis; genome-wide linkage; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goals of the Family Investigation of Nephropathy and Diabetes (FIND) study are to acquire sets of families as well as case-control sets with well-characterized diabetic nephropathy, establish a secure master database, and to localize and identify genes that influence susceptibility to diabetic nephropathy and end stage renal disease. FIND recruits European American (EA), African American (AA), Mexican American (MA) and American Indian (AI) populations to assess genetic contributions that may be specific to various populations. Genetic strategies include genome-wide linkage analyses and Mapping by Admixture Linkage Disequilibrium (MALD). In addition, most of the clinical centers conduct a separate sub-study for diabetic retinopathy. Enrollment of new families for the genome-wide linkage analyses is closed as of 2005. Enrollment of AA and MA case control sets was completed in February 2007. In the years of the recruitment phase for both the family and case-control studies the FIND study screened more than 9500 participants. In order to determine enrollment eligibility, Medical Record Review, Self Reported Medical Questionnaire and biochemical results were reviewed. More than 8600 provided biological samples (blood and urine) for biochemical assay and genetic analysis. B-cells, serum, plasma and urine have been preserved in an archive for future studies. A genome scan was completed in more than 4800 participants from the family study during 2007. Manuscripts reporting the findings are currently in preparation. Additionally, the AA MALD study complted their first analysis and a manuscript reporting the results has been submitted for review to a journal. Identification of genes that influence susceptibility to diabetic nephropathy and/or kidney failure will lead to a better understanding of how serious kidney disease develops. This should eventually lead to improved treatment and prevention. Currently, the FIND study is performing whole genome association in 5200 cases and controls. Data analysis of the results will be performed in 2008.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 家庭调查肾病和糖尿病（发现）研究的主要目标是获取家庭和病例对照组，并具有良好的糖尿病性糖尿病性肾病，建立安全的主数据库，并局部化和识别对糖尿病性肾病敏感性易感性的基因。查找新兵欧洲裔美国人（EA），非裔美国人（AA），墨西哥裔美国人（MA）和美洲印第安人（AI）人口，以评估可能针对各种人群的遗传贡献。遗传策略包括整个基因组的连锁分析和通过混合连接不平衡（MALD）映射的映射。此外，大多数临床中心对糖尿病性视网膜病进行了单独的子研究。截至2005年，新家族的全基因组联系分析的入学率已关闭。2007年2月，AA和MA病例控制集的入学率是在招募阶段完成的。家庭和病例对照研究的研究均研究了研究研究的研究筛查了9500多名参与者。为了确定入学资格，医疗记录审查，自我报告的医学问卷和生化结果。超过8600多个提供生物学样品（血液和尿液）进行生化测定和遗传分析。 B细胞，血清，血浆和尿液已保存在未来研究的档案中。在2007年家庭研究的4800多名参与者中完成了基因组扫描。手稿报告了这些发现目前正在准备中。 此外，AA Mald的研究抱怨他们的第一次分析，并报告了结果的手稿已提交给期刊。 鉴定影响糖尿病性肾病和/或肾衰竭易感性的基因将使人们更好地了解严重的肾脏疾病的发展方式。这最终将导致改善治疗和预防。目前，该发现研究正在在5200例病例和对照组中进行整个基因组关联。 结果的数据分析将在2008年进行。