A NEUROGENOMICS INVESTIGATION OF DEPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 将测量5-羟色胺转运蛋白（5-HTTLPR）多态性对前扣带回（AC）、杏仁核和海马结构（更具体地说，体积和形态）的影响。 将与亚瑟W教授合作进行基于表面的网格建模方法的sMRI数据分析。Toga，加州大学洛杉矶分校神经成像实验室主任。 将使用基于表面的解剖网格建模方法分析每个结构的形态，以产生3D渲染（Thompson等人，1986; Ballmaier等人，2004; Narr等人，2004年）。 通过这种方法，可以进行定量对比。 单相抑郁症中的大脑结构的形态学分析是新颖的，因为先前的研究已经研究了老年抑郁症（Ballmaier等人，2004）和精神分裂症（Narr等人，2004年）。 此外，每个结构将由两个因素（诊断、基因型）建模，并将在诊断（患者、对照）和基因型（SS/SL、LL）的2x2 ANOVA中使用排列检验检查其相互作用。 AC和杏仁核的形态学分析将为功能磁共振成像分析提供信息，并且预计基因型将影响前丘的形态学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The effect of the serotonin transporter (5-HTTLPR) polymorphism on the structure, more specifically the volume and morphology, of the anterior cingulate (AC), amygdala, and hippocampus will be measured. The surface-based mesh modelling method of analysis of the sMRI data will be conducted in collaboration with Professor Arthur W. Toga, Director, Laboratory of Neuro Imaging, UCLA. The morphology of each structure will be analysed with surface-based anatomical mesh modelling methods to produce a 3D rendering (Thompson et al., 1986; Ballmaier et al., 2004; Narr et al., 2004). With this method, quantitative contrasts are possible. The morphological analysis of cerebral structures in unipolar depression is novel as previous studies have investigated geriatric depression (Ballmaier et al., 2004) and schizophrenia (Narr et al., 2004). Moreover, each structure will be modelled by two factors (diagnosis, genotype), and their interaction will be examined in a 2x2 ANOVA of diagnosis (patients, controls) and genotype (SS/SL, LL) with permutation testing. The morphological analysis of the AC and amygdala will inform the fMRI analysis, and it is expected that genotype will affect the morphology of the hippocampi.