A NEUROGENOMICS INVESTIGATION OF DEPRESSION

抑郁症的神经基因组学研究

• 批准号: 7724387
• 负责人: CYNTHIA FU
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724387
• 关键词: Affect; Amygdaloid structure; Analysis of Variance; Anterior; Cerebrum; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnosis; Functional Magnetic Resonance Imaging; Funding; Genetic Polymorphism; Genotype; Grant; Hippocampus (Brain); Image; Institution; Investigation; Laboratories; Measures; Mental Depression; Methods; Modeling; Morphology; Neuro-Oncological Ventral Antigen 2; Patients; Research; Research Personnel; Resources; Schizophrenia; Source; Structure; Surface; Testing; Unipolar Depression; United States National Institutes of Health; base; geriatric depression; novel; professor; serotonin transporter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The effect of the serotonin transporter (5-HTTLPR) polymorphism on the structure, more specifically the volume and morphology, of the anterior cingulate (AC), amygdala, and hippocampus will be measured. The surface-based mesh modelling method of analysis of the sMRI data will be conducted in collaboration with Professor Arthur W. Toga, Director, Laboratory of Neuro Imaging, UCLA. The morphology of each structure will be analysed with surface-based anatomical mesh modelling methods to produce a 3D rendering (Thompson et al., 1986; Ballmaier et al., 2004; Narr et al., 2004). With this method, quantitative contrasts are possible. The morphological analysis of cerebral structures in unipolar depression is novel as previous studies have investigated geriatric depression (Ballmaier et al., 2004) and schizophrenia (Narr et al., 2004). Moreover, each structure will be modelled by two factors (diagnosis, genotype), and their interaction will be examined in a 2x2 ANOVA of diagnosis (patients, controls) and genotype (SS/SL, LL) with permutation testing. The morphological analysis of the AC and amygdala will inform the fMRI analysis, and it is expected that genotype will affect the morphology of the hippocampi.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 将测量5-羟色胺转运体(5-HTTLPR)基因多态性对前扣带回(AC)、杏仁核和海马区结构的影响，更具体地说是体积和形态。分析sMRI数据的基于表面的网格建模方法将与加州大学洛杉矶分校神经成像实验室主任Arthur W.Toga教授合作进行。将使用基于表面的解剖网格建模方法来分析每个结构的形态，以产生3D渲染(Thompson等人，1986；Ballmaier等人，2004；Narr等人，2004)。使用这种方法，定量对比是可能的。单相抑郁的大脑结构的形态分析是新的，因为之前的研究已经调查了老年性抑郁症(Ballmaier等人，2004)和精神分裂症(Narr等人，2004)。此外，每个结构将由两个因素(诊断、基因)建模，它们的交互作用将通过排列测试的诊断(患者、对照)和基因(SS/SL、L1)的2x2方差分析来检验。AC和杏仁核的形态分析将为fMRI分析提供信息，预计基因型将影响海马区的形态。