CORTICAL AND SUBCORTICAL REGIONAL MORPHOLOGY IN UNIPOLAR DEPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在单相抑郁症中经常报告明显的区域异常。 然而，由于图像采集的局限性、分析方法的敏感性和样本特征的混淆，证据是混合的。 我们的目的是研究单相抑郁症患者的皮质和皮质下形态，特别是海马体积和次区域形态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Distinct regional abnormalities are frequently reported in unipolar depression. However, the evidence has been mixed due to limitations in the image acquisition, sensitivity of the analysis methods, and confounds in the sample characteristics. Our aim is to examine cortical and subcortical morphology, in particular hippocampal volume and subregional morphology, in patients with unipolar depression.