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Research Programs-Cancer Genetics

研究项目-癌症遗传学

基本信息

批准号：
7513238
负责人：
Allen Everett Bale
金额：
$ 1.6万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-09 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7513238
关键词：
APC gene Accounting Adenomatous Polyposis Coli Adult Animal Model Basal Cell Nevus Syndrome Basal cell carcinoma Base Sequence Basic Science Biological CDKN2A gene Cancer Family Carcinogen Metabolism Carcinogenesis Mechanism Caring Cells Charge Chemopreventive Agent Clinical Clinical Data Clinical Management Clinical Research Collaborations Colon Carcinoma Core Facility Counseling CpCp DNA Repair Defect Diagnosis Direct Costs Discipline of obstetrics Disease Management Drosophila genus Environmental Carcinogens Environmental Risk Factor Epidemiologist Epidemiology Epigenetic Process Event Faculty Frequencies Funding Gene Expression Regulation Gene Mutation Genes Genetic Genetic Counseling Genetic Polymorphism Genetic Predisposition to Disease Genetic Programming Genetic Variation Genomics Germ-Line Mutation Goals Growth Gynecology Health Services Research Hereditary Disease Hereditary Malignant Neoplasm Hereditary Melanoma Immune Individual Inherited Joints Laboratories Laboratory Scientists Leadership Link Maintenance Malignant Childhood Neoplasm Malignant Neoplasms Methods Mismatch Repair Molecular Mutate Mutation Neoplasms Oncogenes Operative Surgical Procedures Ovarian PTCH gene Patients Peer Review Pharmaceutical Preparations Phase I Clinical Trials Play Population Predisposition Prevalence Prevention Primary Health Care Professional counselor Publishing Regulation Relative Risks Reproduction spores Research Research Personnel Resource Sharing Retinoblastoma Risk Risk Factors Role Scientist Seeds Services Signal Transduction Pathway Skin Skin Cancer Specimen Sun Exposure Susceptibility Gene TNFRSF5 gene Testing Therapeutic Radiology specialty Work base cancer genetics cancer prevention cancer risk cancer therapy cancer type cell growth cost drug development environmental agent functional genomics gene cloning gene function genetic variant improved insight interest melanoma member novel oncology polyposis programs research study size skin color tool trait tumor

项目摘要

The Cancer Genetics Program (CGP) was founded in 1995 as a developing program, with the YCC providing seed money to hire a genetic counselor, initiate a coordinated clinical and research endeavor, and fund a portion of the Program Leader's effort. In 1996, a supplement was obtained to initiate a core facility for acquiring clinical data and biological specimens from cancer families. Under the leadership of Dr. Alan Bale, the Program has nearly doubled in size since its inception, and now includes 17 faculty members representing 8 departments. Cancer Genetic Counseling has grown to include 4 counselors and now functions as a Shared Resource, providing counseling services for research studies as well as for clinical support. The central themes of this program are identification of genes underlying hereditary cancer predisposition, studying the role of these genes in sporadic cancer, elucidating gene function, and applying novel research findings to diagnosis, disease management, and rational drug development. An example of the type of research this program supports is cloning the gene for the basal cell nevus syndrome (BCNS), elucidating the function of the gene using Drosophila as a model organism, and conducting an NCI-supported, phase I clinical trial using a drug specifically targeting this key molecular defect in skin cancer. The same strategy is being applied to a variety of other malignancies. The Program thus serves as a bridge between the Cancer Prevention & Control Program >(CPCP) and the Gene Regulation & Functional Genomics Program (GRFGP). While our Program members use molecular tools to identify and characterize the function of genes that is responsible for hereditary predisposition to cancer, GRFGP is charged with characterizing the genetic and epigenetic changes in sporadic tumors. Since many of the same genes play a role in both sporadic and hereditary cancer, discoveries by members of either program have clear relevance to the other. A new joint project of these two programs is microarray-based sequencing of all cancer predisposition genes. Together with CPCP, our Members also participate in efforts to examine the interplay of environmental and genetic factors in cancer risk, notably ovarian and skin cancer. The skin cancer work is part of a P50 SPORE relating common genetic variants of skin color and environmental risk factors. The Program members research funding over the past year include totaling $4.7 million direct costs ($6.67 million total costs) of which $1.2 million direct costs ($1.7 million total costs) is from the NCI. Over the past 7 years, the Program has published over peer-reviewed 164 articles of which approximately 39% resulted from interprogrammatic collaboration and 9.1% resulted from intraprogrammatic collaboration.

癌症遗传学项目（CGP）成立于1995年，是一个发展中的项目，由YCC提供