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CORE--LABORATORY ANIMAL CARE RESOURCE

核心--实验动物护理资源

基本信息

批准号：
7417854
负责人：
THOMAS E MARTIN
金额：
$ 26.69万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-01 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7417854
关键词：
Accreditation Address Adopted Air American Animal Care and Use Committees Animal Experimentation Animal Husbandry Animal Technicians Animals Antibody Formation Antineoplastic Agents Ascites Attention Backcrossings Beds Biological Assay Breeding Cancer Center Support Grant Canis familiaris Carcinogens Caring Certification Collaborations Collection Complex Cost Control Crossbreeding Daily Data Decontamination Diagnostic Doctor of Philosophy Ensure Environment Equipment Equipment and supply inventories Extramural Activities Faculty Food Funding Genetic Grant Health Health Status Horizontal Disease Transmission Human Resources Hybridomas IACUC Immune Inbred Mouse Incineration Institutes Institution International Knockout Mice Laboratories Laboratory Animal Medicine Laboratory Animal Science Licensing Livestock Maintenance Medical Medical Research Medical Surveillance Monitor Mus New York Nude Rats Occupational Operative Surgical Procedures Oryctolagus cuniculus Pathology Peer Review Phenotype Predisposition Procedures Process Production Protocols documentation Rattus Registries Research Research Personnel Resources Rodent Safety Sampling Schedule Sentinel Services Shipping Ships Source Standards of Weights and Measures Stream Surveillance Program System Techniques Technology Therapeutic Training Transgenic Organisms Vendor Veterinarians Viral Antibodies Water Work animal care animal facility animal resource base cancer cell cost gene therapy germ free condition knockout gene laboratory facility member mutant novel strategies pathogen polyclonal antibody prevent programs quality assurance wasting

项目摘要

The Laboratory Animal Resource (LAR) is responsible for laboratory animal care and use primarily by investigators at RPCI with peer-reviewed funding. In June 2002, the Resource was granted full accreditation by the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). The Resource provides specialized animal husbandry; veterinary medical care; animal health surveillance; diagnostic laboratory facilities; research technical services and resources including genetically defined mice; a surgical program and technician; and faculty training in support of more than 150 Institute Animal Care and Use Committee-approved animal use protocols. Additional services include polyclonal antibody production in rabbits, hybridoma ascites production and collection in mice, and inbred and immune-deficient rodent production. Daily animal inventories of 21,000, include a variety of rodent species, rabbits, dogs and occasionally farm animals. The Resource Director is a New York State licensed veterinarian who has been trained in pathology (PhD) and is Board-Certified in Laboratory Animal Medicine (ACLAM). Fifteen members of the technical staff are certified through the Certification and Registry Board of the American Association for Laboratory Animal Science (AALAS). The Laboratory Animal Resource is located in the four-story 39,000 nsf vivarium within the Medical Research Complex (MRC), which opened in 1998. Additional newly renovated space is available in the Cancer Cell Center, for a total of approximately 47,000 nsf. Laboratories for work with gene knockout and transgenic technologies in mice are immediately adjacent to animal holding rooms. Continued support through the CCSG will permit the Resource to provide a standard of care and use that meets or exceeds applicable state and federal standards, maintain full AAALAC International accreditation, and furnish investigators with a comprehensive program for safe, appropriate and cost-effective research animal use.

实验动物资源(LAR)负责实验动物的护理和使用，主要由RPCI的研究人员使用同行评审的资金。2002年6月，该资源获得国际实验动物保护评估和认可协会(AAALAC International)的全面认可。该资源提供专门的畜牧业；兽医医疗保健；动物健康监测；诊断实验室设施；研究技术服务和资源，包括基因定义的小鼠；外科项目和技术员；以及支持150多个研究所动物护理和使用委员会批准的动物使用方案的教师培训。其他服务包括在兔子身上生产多克隆抗体，在老鼠身上生产和收集杂交瘤腹水，以及近亲繁殖和免疫缺陷啮齿动物的生产。每天有21,000只动物的库存，包括各种啮齿动物、兔子、狗，偶尔还有农场动物。资源主任是一名纽约州注册兽医，曾接受过病理学(PhD)培训，并在实验动物医学(ACLAM)方面获得董事会认证。15名技术人员通过了美国实验动物科学协会(AALAS)的认证和注册委员会的认证。实验动物资源位于1998年开放的医学研究综合体(MRC)内的四层楼高的NSF 39,000室内。癌症细胞中心还提供了新装修的额外空间，总共约有47,000个NSF。用于基因敲除和转基因工作的实验室老鼠身上的技术紧邻动物拘留室。通过CCSG的持续支持，资源中心将能够提供达到或超过适用的州和联邦标准的护理和使用标准，保持AAALAC国际全面认证，并为研究人员提供安全、适当和经济高效的研究动物使用综合计划。