Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood

描述（由申请人提供）：本研究的目的是研究暴露于流行杀虫剂对399名儿童神经行为结果的影响。我们将包括在新生儿期间观察到的产前暴露效应的评估，以及出生后到六岁的暴露效应。儿童目前正在参加一项队列研究，调查暴露于各种环境毒物对健康、发育和行为的影响，并计划随访至两岁。最初的资金来自NIEHS/EPA。生物样本将用于评估产前（产妇尿液、婴儿胎便）和产后（儿童尿液）接触杀虫剂的情况。我们将使用新生儿重症监护病房网络神经行为量表（NNNS）检查新生儿在出生后36小时内和4周家访期间的神经行为结果，以评估产前暴露于流行杀虫剂的早期影响。该研究将扩大该队列的随访，包括4,5和6岁时的评估或发展，认知，运动技能和行为，以检查出生后接触杀虫剂的影响。分析将采用多变量和因果模型技术。潜在的协变量将包括孕妇在怀孕期间使用药物和酒精、妊娠结局和婴儿特征、孕妇特征和家庭环境质量、社会经济地位变量、铅和烟草暴露以及其他适当的变量。在早期访问时收集的生物样本和神经行为测试数据也将提供。我们提出了以下目标：目的1：通过收集孕妇孕期尿液和出生后不久的胎便中的生物标志物来确定产前暴露于流行杀虫剂与新生儿期间用NNNS测量的神经行为之间的关系。目的2：通过测定4 - 6岁儿童尿液中杀虫剂含量来确定出生后暴露于流行杀虫剂与神经行为之间的关系。我们将仔细检查产前和产后暴露于流行杀虫剂的影响，使用多个时间点的多种生物标志物和敏感的神经行为评估工具，从新生儿期到五岁。本研究利用已建立的队列研究的研究基础，提供了一个独特的机会来检查产前和产后暴露于杀虫剂对从新生儿期到6岁的轨迹中神经行为结果的早期影响。

DESCRIPTION (provided by applicant): The objective of this study is to examine the effects of exposure to prevalent insecticides on neurobehavioral outcomes in a cohort of 399 children. We will include an evaluation of prenatal exposure effects observed during the newborn period, as well as postnatal exposure effects through age six. Children are currently enrolled in cohort study investigating the health, developmental, and behavioral consequences of exposure to a variety of environmental toxicants and with planned follow-up to age two. Original funding was through NIEHS/EPA. Biological samples will be used to assess exposure to insecticides prenatally (maternal urine, infant meconium) and postnatally (child urine). We will examine newborn neurobehavioral outcomes within the first 36 hours of life and during a home visit at 4 weeks, using the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS), to assess the earliest effects of prenatal exposure to prevalent insecticides. The study will extend follow-up of this cohort to include assessments or development, cognition, motor skills, and behaviors at ages 4, 5, and 6 in an effort to examine the effects of postnatal exposure to insecticides. Analyses will employ multivariate and causal modeling techniques. Potential covariates will include maternal drug and alcohol use during pregnancy, pregnancy outcomes and infant characteristics, maternal characteristics and qualities of the home environment, socioeconomic status variables, lead and tobacco exposure, and other variables as appropriate. Data from biological samples and neurobehavioral testing collected at earlier visits will also be available. We propose the following aims: AIM 1 To characterize the association of prenatal exposure to prevalent insecticides, as determined by biomarkers collected in maternal urine during pregnancy and in meconium shortly after birth, with neurobehavior during the newborn period measured with the NNNS. Aim 2 To characterize the association of postnatal exposure to prevalent insecticides, as determined by measures of insecticides in child urine with neurobehavior at ages four to six years. We will carefully examine the effects of prenatal and postnatal exposure to prevalent insecticides using multiple biological markers of exposure at numerous time points and sensitive neurobehavioral assessment tools from the newborn period through age five years. This study offers a unique opportunity to examine the early effects of prenatal and postnatal exposure to insecticides on neurobehavioral outcomes in a trajectory from the newborn period through age six years, while utilizing the research infrastructure of an established cohort study.