Mechanisms of H. pylori-Induced Hypochlorhydria

幽门螺杆菌引起胃酸过少的机制

• 批准号: 8145073
• 负责人: ADAM J SMOLKA
• 金额: $ 42.05万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145073
• 关键词: Acids; Acute; Address; Atrophic Gastritis; Award; Binding; Binding Sites; Biochemical; Biological; Biopsy; Carcinogens; Cells; Cytotoxin; Development; Dysplasia; EGF gene; Environment; Epithelial Cells; Event; Experimental Designs; Foundations; Functional disorder; Gastric Acid; Gastric Adenocarcinoma; Gastric Parietal Cells; Gastric mucosa; Gastritis; Gene Expression; Genes; Genetic; Genetic Transcription; Goals; H(+)-K(+)-Exchanging ATPase; Helicobacter Infections; Helicobacter pylori; Human; Hypochlorhydria; Infection; Integrins; Intestinal Metaplasia; Lesion; Ligands; Malignant Neoplasms; Measures; Mediating; Modeling; Molecular; Oncogene Proteins; Pathogenicity Island; Pathway interactions; Patients; Peptide Hydrolases; Peptidoglycan; Phenotype; Physiological; Pilum; Premalignant; Protein Tyrosine Kinase; Proteins; Proton Pump; Regulation; Repression; Response Elements; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Staging; Stomach; Structural Protein; System; TNFRSF5 gene; Testing; Virulence Factors; base; clinically relevant; improved; innovation; insight; mutant; promoter; public health relevance; receptor; response

项目成果

Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein.

• DOI: 10.1016/j.ejcb.2010.11.006
• 发表时间: 2011-11
• 期刊: European journal of cell biology
• 影响因子: 6.6
• 作者: Nicole Tegtmeyer;S. Backert

Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α.

• DOI: 10.1371/journal.pone.0019614
• 发表时间: 2011-05-09
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kumar Pachathundikandi S;Brandt S;Madassery J;Backert S
• 通讯作者: Backert S