Vitamin D Production by Sperti Lamp in Fat Malabsorption Patients

描述（申请人提供）：维生素D在儿童和成人的钙代谢和骨骼健康中起着至关重要的作用。现在人们认识到，体内的每个组织和细胞都有维生素D受体，因此体内的每个组织和细胞都是维生素D作用的目标。研究表明，增加阳光照射和增加维生素D摄入量可以降低许多慢性疾病的风险，包括自身免疫性疾病、心脏病、传染病、II型糖尿病和癌症。维生素D缺乏和不足是美国儿童和成人中最常见的营养缺乏症和医疗状况。儿童和成人维生素D的主要来源是暴露在阳光下。饮食中维生素D很少，因此要维持正常健康的维生素D水平就需要服用维生素D补充剂。吸收不良的病人以及体弱多病、无法接触阳光的儿童和成人患维生素D缺乏症及其健康后果的风险特别高。人工紫外线照射也是一种很好的来源的维生素D KBD inc .)是一个小企业,使Sperti维生素D生产灯,50多年以来已存在和销售生产维生素D灯已经被修改,这样大部分的光谱输出在UVB区域从而最大限度生产维生素D这个格兰特的目标是把这个新设计的灯和测试其有效性在患者炎性肠道产生维生素D患有2、3、4和5型皮肤的IBD成年患者将接受Sperti荧光灯发出的皮下剂量的UVB辐射，每周照射3次，持续3个月。25-羟基维生素D的血液水平，维生素D状态的测量，将是该研究的主要结果。这项研究的结果将提供功效数据，以支持这种新型维生素D生产荧光灯的商业开发，不仅适用于吸收不良综合征的患者，也适用于养老院的老人，以及不能暴露在阳光下、难以服用维生素D补充剂的儿童和成人。

DESCRIPTION (provided by applicant): Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the body is a target for vitamin D action. Studies suggest that increased exposure to sunlight and increased vitamin D intake reduces risk of many chronic diseases including autoimmune diseases, heart disease, infectious diseases, type II diabetes and cancer. Vitamin D deficiency and insufficiency is the most common nutritional deficiency and medical condition in children and adults throughout the United States. The major source of vitamin D for children and adults is exposure to sunlight. There is little vitamin D in the diet and thus to maintain a normal healthy vitamin D status requires taking a vitamin D supplement. Patients with malabsorption and children and adults who are infirm and unable to be exposed to any sunlight are at particularly high risk for vitamin D deficiency and its health consequences. Artificial ultraviolet irradiation is also a good source of vitamin D. KBD Inc. is a small business that makes the Sperti vitamin D producing lamp that has been in existence for more than 50 years and marketed for producing vitamin D. The lamp has been modified so that most of the spectral output is in the UVB region thus maximally producing vitamin D. The goal of this grant is to take this newly designed lamp and test its effectiveness in producing vitamin D in patients with inflammatory bowel disease who have been demonstrated to malabsorb vitamin D. Adult IBD patients with skin types 2,3,4 and 5 will be exposed to suberythemal dose of UVB radiation from the Sperti fluorescent lamp three times a week for three months. Blood levels of 25-hydroxyvitamin D, a measure of vitamin D status, will be the primary outcome for the study. Results from this study should provide efficacy data to support the commercial development of this novel vitamin D producing fluorescent lamp not only for patients with malabsorption syndromes but also elderly in nursing homes and for children and adults who cannot be exposed to sunlight and have a difficult time taking a vitamin D supplement. PUBLIC HEALTH RELEVANCE: The goal of this grant is to obtain data that exposure to a novel Sperti fluorescent vitamin D producing lamp is effective in improving the vitamin D status of patients with inflammatory bowel disease who have documented vitamin D malabsorption. It is anticipated that results from this grant will provide the impetus for the small business KBD Inc. to market and sell its product to patients who suffer from the intestinal malabsorption syndromes and who are vitamin D deficient.