Development of a Wearable Passive Vibration Therapy System for the Lower Extremit

开发可穿戴式下肢被动振动治疗系统

• 批准号: 7927340
• 负责人: Jeffrey Michael Leismer
• 金额: $ 20万
• 依托单位: VIBETECH, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2011-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7927340
• 关键词: Affect; American; Arthritis; Assisted Living Facilities; Bed rest; Caring; Clinical Trials; Development; Device Designs; Devices; Diabetes Mellitus; Dropout; Effectiveness; Elderly; Ensure; Environment; Equilibrium; Equipment; Exercise; Fracture; Funding; Future; Gait; Goals; Grant; Health; Health Care Costs; Hip Fractures; Hospitals; Intervention; Limb structure; Location; Low Back Pain; Lower Extremity; Marketing; Measures; Muscle; Musculoskeletal; Musculoskeletal System; Nursing Homes; Obesity; Osteoporosis; Performance; Persons; Physical Capacity; Pilot Projects; Population; Preclinical Testing; Preparation; Prevalence; Public Health; Quality of life; Readiness; Regimen; Reporting; Risk; Safety; Skilled Nursing Facilities; Speed; Staging; Symptoms; System; Technology; Testing; Validation; Vendor; Work; base; bone; bone metabolism; bone quality; bone strength; bone turnover; combat; cost; design; disability; fall risk; falls; hypertensive heart disease; improved; meetings; muscle strength; preclinical study; prevent; programs; prototype; public health relevance; treatment duration; vibration

DESCRIPTION (provided by applicant): VibeTech, Inc. proposes the development and preclinical testing of a Wearable Passive Vibration Therapy (WPVT) System for the Lower Extremity for use by older adults with limited or no mobility. The device is intended to deliver stimulation to the musculoskeletal system to reduce or reverse bone and muscle loss associated with disuse of the affected limb(s). Annual healthcare costs due to the physical inactivity of Americans are in the hundreds of billions of dollars. Arthritis, diabetes, heart disease, hypertension, low back pain, obesity, osteoporosis, and other common conditions are the result of or result in reduced activity level and diminished quality of life for many millions of Americans. Exercise is an option that can alleviate many symptoms associated with each condition. However, exercise programs have a high dropout rate and persons with the most serious conditions cannot use equipment available on the market. As such, the proposed WPVT device will deliver a passive, vibration-based workout to persons with limited or no mobility, thus providing an opportunity for millions of people to commence a regimen of musculoskeletal stimulation aimed at increasing physical capacity. The prevalence of debilitating health conditions such as those associated with limited or no mobility is especially high in nursing homes, assisted living centers, and hospitals. These are the locations where VibeTech aims to place its products to achieve the largest potential impact at improving quality of life and reducing cost of care. Funding for this grant will support the development and testing of three prototype WPVT devices. The devices will be used in preclinical tests over the course of a 3-month treatment period to evaluate their effectiveness at improving functional strength measures, correlates to falls risk (gait speed and balance), and bone metabolism in older adults residing within a nursing home. Future work will involve lengthier clinical trials and will target additional populations with limited or no mobility to evaluate the ability of the WPVT device to improve bone quality, muscle performance, and balance over a long-term treatment period in a range of populations that can benefit from passive musculoskeletal stimulation. PUBLIC HEALTH RELEVANCE: The Wearable Passive Vibration Therapy (WPVT) device offers promise of reducing fracture risk associated with falls in older adults by improving strength, balance, gait, and bone quality, but perhaps the most useful feature of this device is its ability to passively deliver musculoskeletal stimulation to persons recovering from falls-related hip fractures (e.g., those in a bed rest or other reduced activity environments). Typically, 24% of older adults die from indirect health complications within one year of receiving a hip fracture as a result of reduced muscle strength and inactivity caused by physical disability. The WPVT device is specifically developed to provide the required stimulation to combat reduced muscle strength and physical disability, thus helping older adults increase their odds for survival after a hip fracture (or preventing a hip fracture from occurring in the first place).

描述(申请人提供)：VibeTech，Inc.建议为行动不便或行动不便的老年人开发一种可穿戴的被动振动疗法(WPVT)系统并进行临床前测试。该设备旨在向肌肉骨骼系统提供刺激，以减少或逆转因停用受影响肢体而导致的骨骼和肌肉损失(S)。由于美国人缺乏身体活动，每年的医疗费用高达数千亿美元。关节炎、糖尿病、心脏病、高血压、腰痛、肥胖、骨质疏松症和其他常见疾病是数百万美国人运动水平降低和生活质量下降的结果或结果。锻炼是一种选择，可以缓解与每种情况相关的许多症状。然而，锻炼计划的辍学率很高，病情最严重的人不能使用市场上提供的器材。因此，拟议的WPVT设备将为行动不便或行动不便的人提供被动的、基于振动的锻炼，从而为数百万人提供机会，开始旨在提高体能的肌肉骨骼刺激方案。在养老院、辅助生活中心和医院，与行动能力有限或没有行动能力相关的令人衰弱的健康状况的发生率尤其高。这些都是VibeTech致力于将其产品放置在这些地点，以在提高生活质量和降低护理成本方面实现最大的潜在影响。这笔赠款的资金将支持三个WPVT设备原型的开发和测试。这些设备将在为期3个月的治疗期内用于临床前测试，以评估它们在改善功能强度测量、与跌倒风险(步态速度和平衡)以及居住在疗养院的老年人的骨代谢相关方面的有效性。未来的工作将涉及更长的临床试验，并将针对更多行动能力有限或没有行动能力的人群，以评估WPVT设备在一系列可以受益于被动肌肉骨骼刺激的人群中在长期治疗期内改善骨骼质量、肌肉性能和平衡的能力。 与公共健康相关：可穿戴式被动振动疗法(WPVT)设备有望通过改善力量、平衡、步态和骨骼质量来降低老年人跌倒造成的骨折风险，但或许该设备最有用的功能是它能够被动地为跌倒相关髋部骨折恢复者(如卧床休息或其他活动减少环境中的患者)提供肌肉骨骼刺激。通常，24%的老年人在髋部骨折后一年内死于间接健康并发症，这是由于身体残疾导致的肌肉力量减少和缺乏活动造成的。WPVT设备是专门开发的，旨在提供必要的刺激，以对抗肌肉力量下降和身体残疾，从而帮助老年人增加髋部骨折后的存活几率(或从一开始就防止髋部骨折的发生)。