Molecular based strategies to generate protective immune responses to HIV-1
Molecular based strategies to generate protective immune responses to HIV-1
批准号:
7927825
负责人:
YOSEF REFAELI
金额:
$17.18万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-03-01 至 2011-08-31
关键词:
Acquired Immunodeficiency SyndromeAdjuvantAdjuvant StudyAnimalsAntibodiesAntibody FormationAntibody RepertoireAntibody SpecificityAntigenic DiversityAntigensAutoantibodiesAutoimmunityB-LymphocytesBindingBiologicalCancer PatientCardiolipinsCellsClinical TrialsCommunicable DiseasesDevelopmentDoseEpitopesExposure toFutureGaggingGenerationsGoalsHIVHIV AntibodiesHIV AntigensHIV Envelope Protein gp160HIV Envelope Protein gp41HIV InfectionsHIV envelope proteinHIV-1HemagglutininHumanImmune responseImmune systemImmunityImmunizationIndividualInflammatoryInfluenzaInfusion proceduresLymphoidLymphoid CellMalariaMolecularMonoclonal AntibodiesMusOilsPatientsPatternPhasePreparationProceduresProductionProtein IsoformsProteinsPublic HealthRelaxationSelf ToleranceSerumSignal TransductionSpecificityT-LymphocyteTechnologyTestingTherapeuticTo autoantigenUp-RegulationVaccinationVaccine AdjuvantVaccine AntigenVaccine DesignVaccinesVariantVirusanergyautoreactive B cellbasecomplementarity-determining region 3designefficacy testingexperiencegag Gene Productsgp160human MPP1 proteinimmunogenicimprovedin vivolarge scale productionneutralizing antibodyneutralizing monoclonal antibodiesnovelnovel strategiesnovel vaccinesperipheral toleranceprophylacticpublic health relevanceresponsetherapeutic vaccine
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Using a new approach to adjuvant design we have identified a molecular based adjuvant that enhances immune response by several criteria including, an earlier response, a stronger response to more parts of the vaccine, and the ability to respond to very small amounts of vaccine. Phase I of this project involves applying the same technology to HIV-1 antigens. Phase II of the project will entail optimizing large-scale production of our adjuvant for studies in larger animals and eventual testing in human clinical trials.
PUBLIC HEALTH RELEVANCE: This project seeks to further characterize a novel vaccine adjuvant that we have discovered that appears to enhance immune responses to difficult targets. Once this adjuvant has been validated against HIV-1 targets, the long-term goal for benefiting public health will be to use this adjuvant to improve vaccine strategies that target other infectious diseases such as Influenza and Malaria in addition to improving therapeutic vaccine approaches for cancer patients.
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会议论文
The consequences of loricrin deficiency on epidermal barrier function
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批准号:8871513
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资助金额:$32.99万
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财政年份:2011
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负责人:YOSEF REFAELI
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依托单位:
The consequences of loricrin deficiency on epidermal barrier function
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批准号:8488416
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依托单位:
The consequences of loricrin deficiency on epidermal barrier function
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批准号:8706798
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项目类别:
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资助金额:$32.33万
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财政年份:2011
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批准号:8326630
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Generation of HIV resistant cells from protein transduced hematopoetic stem cell
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MYC-induced breach of B-cell anergy in AIDS-related NHLs
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MYC-induced breach of B-cell anergy in AIDS-related NHLs
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资助金额:$24.92万
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财政年份:2006
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依托单位:
MYC-induced breach of B-cell anergy in AIDS-related NHLs
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项目类别:
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资助金额:$36.11万
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财政年份:2006
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负责人:YOSEF REFAELI
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依托单位:
Genetics
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批准号:7929675
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项目类别:
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资助金额:$15.66万
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财政年份:--
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负责人:YOSEF REFAELI
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依托单位:
Genetics
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批准号:8134393
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项目类别:
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资助金额:$16.12万
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财政年份:--
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负责人:YOSEF REFAELI
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依托单位:
海外基金