Administrative Core

该计划项目组(PPG)声明的目标是确定药理学的分子靶标 在实验室模型中进行干预，为这些靶点设计合理的辅助神经保护药物 单独或联合使用，然后在体外和体内的神经艾滋病模型中进行测试，最终带来 这些策略中最成功的是在这笔赠款的授权期内进行第一阶段试验。核心A将 为该PPG提供全面的行政支持，并将协调所有项目和 核心。因此，该核心的职能是：(1)为每个项目/核心提供财政监督，并 总的PPG；(2)协调和精简这个PPG中出现的知识产权问题；(3) 及时向本PPG的所有调查人员提供数据信息/交换；(4)与CORE合作 D(生物统计学)根据NIH现行政策指导方针提供数据共享；(5)提供 为PPG调查员和我们的外部咨询人员之间的定期会议提供组织支持 委员会(选管会)；以及最终，(6)精简我们的研究结果，并提供一个平台，以推动 最有希望的附加神经保护策略，用于考虑和纳入更高级的 未来的临床试验。核心A成员和PPG的其他成员之间的互动将提供最佳 为迅速完成我们的方案目标创造智力和行政环境。

The stated aims of this Program Project Group (PPG) are to define molecular targets for pharmacologic intervention in laboratory models, design rational adjunctive neuroprotective drugs for these targets, either singly or in combination, then test them in in vitro and in vivo models of neuroAIDS, and ultimately bring the most successful of these strategies to Phase 1 trials within the award period of this grant. Core A will provide overall administrative support for this PPG, and will also coordinate the activities of all Projects and Cores. Thus, the functions of this Core are to: (1) provide fiscal oversight for each of the Projects/Cores and the overall PPG; (2) coordinate and streamline the intellectual property issues that arise in this PPG; (3) provide data information/exchange in a timely fashion to all investigators in this PPG; (4) in concert with Core D (Biostatistics) provide data sharing in accordance with the current NIH policy guidelines; (5) provide organizational support for regular meetings between the PPG investigators and our external advisory committee (EAC); and ultimately, (6) streamline our findings and provide a platform for advancement of the most promising adjunctive neuroprotective strategies for consideration and inclusion in more advanced future clinical trials. Interactions between Core A members and the rest of the PPG will provide the optimal intellectual and administrative environment for expeditious completion of our programmatic goals.