Implantable Sensor for Transplant Tissue Monitoring

用于移植组织监测的植入式传感器

• 批准号: 7689300
• 负责人: MARK A. WILSON
• 金额: $ 65.62万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689300
• 关键词: Acute; Address; Advanced Development; Anastomosis - action; Animal Testing; Attention; Biocompatible; Biomedical Engineering; Blood Vessels; Blood flow; Caring; Clinical; Clinical Protocols; Collaborations; Communication; Complex; Coupled; Critical Care; Data; Development; Diagnostic; Doctor of Philosophy; Early Diagnosis; Electronics; Emergency Medicine; Engineering; Goals; Hemoglobin; Homeostasis; Impairment; Implant; Injury; Intervention; Intestines; Kidney; Laboratories; Lead; Malignant Neoplasms; Measurement; Medical; Metabolic; Methodology; Microfabrication; Miniaturization; Monitor; Morbidity - disease rate; Operative Surgical Procedures; Optics; Organ; Organ Transplantation; Oxygen; Patient Monitoring; Patients; Perfusion; Physicians; Physiological; Principal Investigator; Procedures; Process; Protocols documentation; Publishing; Recording of previous events; Relative (related person); Research; Research Personnel; Research Project Grants; Risk; Screening procedure; Site; Stress; System; Techniques; Technology; Telemetry; Testing; Texas; Time; Tissues; Transplantation; Transplanted tissue; Universities; Vascular blood supply; Venous; Work; base; biomaterial compatibility; clinical application; computerized data processing; data integrity; design; flexibility; implantation; improved; instrument; instrumentation; interest; liver transplantation; minimally invasive; monitoring device; multidisciplinary; operation; photonics; prevent; programs; prototype; reconstruction; research facility; sample fixation; sensor; tool

DESCRIPTION (provided by applicant): An implantable tissue monitoring system is proposed to address the limitations of existing instrumentation for tissue perfusion monitoring for a variety of clinical applications. The implanted system is intended as a minimally-invasive screening tool that provides real-time tissue perfusion and oxygen assessment to prompt physician attention and the application of established diagnostics and invasive corrective procedures, in particular for liver transplant. The system relies on photonics-based measurements coupled with integrated signal processing and data telemetry to provide real-time monitoring of tissue perfusion. The methodology and implementation are directed towards surgical and post-surgical procedures and have application to a number of additional monitoring scenarios including emergency medicine and critical care. Miniaturization will be accomplished using microfabrication techniques allowing complete implantation of the sensor system in the precise region of interest, either as a subdermal or deep tissue implant. Signal processing will be incorporated in the implanted micro-system to reduce the data communication requirements and potentially allow automated process control. A three-wavelength system will initially be designed and tested in a number of clinical scenarios to assess relative levels of perfusion and to establish clinical protocols for use of this technique. Additional capabilities for quantification of arterial and venous oxygen saturation will be developed to permit assessment of organ oxygen utilization. Biocompatible encapsulation materials will be utilized allowing long-term monitoring scenarios. The use of spread-spectrum RF data communications will both assure high-integrity data telemetry and avoid RF interference to existing medical instrumentation systems. This will also permit deployment of multiple sensors in close proximity for more comprehensive patient monitoring applications. The end goal of the project is to produce a working implantable system with well-established clinical applications and associated protocols demonstrated through animal testing. A strong collaboration of established medical, bioengineering, and engineering professionals with a published history of collaboration exists among the Principal Investigator, Mark A. Wilson, MD, PhD (University of Pittsburgh), and Lead Investigators, M. Nance Ericson, PhD (Oak Ridge National Laboratory) and Gerard L. Cote, PhD (Texas A&M University). Dr. Wilson is responsible for overall study coordination and clinical application studies. Dr. Ericson leads efforts for development of electronics, and Dr. Cote is responsible for optical sensing strategies. This collaboration provides the expertise and research facilities necessary to successfully address important clinical patient monitoring problems using a combination of medical photonics and smart medical instrumentation in a unique integrated package.

描述（由申请人提供）：提出了一种可植入组织监测系统，以解决用于各种临床应用的组织灌注监测的现有仪器的局限性。植入系统旨在作为一种微创筛查工具，提供实时组织灌注和氧气评估，以提示医生注意并应用已建立的诊断和侵入性纠正程序，特别是对于肝移植。该系统依靠基于光子学的测量以及集成信号处理和数据遥测来提供组织灌注的实时监测。该方法和实施针对手术和术后程序，并适用于许多其他监测场景，包括急诊医学和重症监护。将使用微加工技术来实现小型化，允许将传感器系统完全植入到感兴趣的精确区域中，无论是皮下植入还是深层组织植入。信号处理将被纳入植入的微系统中，以减少数据通信要求，并有可能实现自动化过程控制。最初将在许多临床场景中设计和测试三波长系统，以评估灌注的相对水平并建立使用该技术的临床方案。将开发量化动脉和静脉氧饱和度的附加功能，以评估器官的氧利用率。将使用生物相容性封装材料来实现长期监测场景。扩频射频数据通信的使用既可以确保高完整性的数据遥测，又可以避免对现有医疗仪器系统的射频干扰。这也将允许在附近部署多个传感器，以实现更全面的患者监测应用。该项目的最终目标是生产一个可工作的植入系统，具有完善的临床应用和通过动物测试证明的相关协议。首席研究员 Mark A. Wilson 博士（匹兹堡大学）与首席研究员 M. Nance Ericson 博士（橡树岭国家实验室）和 Gerard L. Cote 博士（德克萨斯农工大学）。 Wilson博士负责整体研究协调和临床应用研究。 Ericson 博士领导电子产品的开发工作，Cote 博士负责光学传感策略。此次合作提供了必要的专业知识和研究设施，通过将医疗光子学和智能医疗仪器结合在一个独特的集成包中，成功解决重要的临床患者监测问题。