Broad Institute Comprehensive Screening Center

布罗德研究所综合筛查中心

• 批准号: 7938954
• 负责人: STUART L SCHREIBER
• 金额: $ 1424.77万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938954
• 关键词: Broad; Institute; Comprehensive; Screening; Center

Biomedical researchers in the 21st century work in the epicenter of an explosion in the understanding of human disease. The complete sequences of relevant genomes, like the human and various infectious organisms, lay the foundation for the next steps in probing molecular mechanisms of disease. Broad Institute researchers recognized at an early stage of this revolution that the perturbation of the cellular pathways that underlie phenotypic changes with small molecules will make it possible to dissect cell circuitry and disease biology, thus enabling a path forward to correcting human diseases. We have operated a Screening Facility in a production mode over the past ten years in an open data-sharing environment, created the first comprehensive and public small-molecule database and analysis environment containing over 20 million binding and assay-well measurements, a novel chemical biology information model and many powerful analysis tools, and, in 2007, made a substantial investment in personnel, screening automation, LIMS and robotics that has substantially increased these already significant production capabilities. This screening facility resides within a rich environment focused on small molecules and small-molecule screening integrated with disease biology and genome biology. We propose here a plan to operate a Comprehensive Screening Center at the Broad Institute of Harvard and MIT (BCSC), leveraging and complementing existing organizational and infrastructure initiatives by collaborating with a wider MLPCN research community.

21世纪的生物医学研究人员在理解人类疾病的爆炸中心工作。相关基因组的完整序列，例如人类和各种感染性生物，为探测疾病分子机制的下一步奠定了基础。广泛的研究所的研究人员在这次革命的早期阶段认识到，与小分子相关的表型变化的细胞途径的扰动将使您可以剖析细胞回路和疾病生物学，从而使纠正人类疾病的前进。在过去的十年中，我们在开放的数据共享环境中在生产模式下运营了筛查设施，创建了第一个全面的，公共的小型分子数据库和分析环境，其中包含超过2000万个具有约束力和测定孔测量的测量结果，一种新型的化学生物学信息模型和许多强大的分析工具，并在2007年对人员进行了大量的自动化，从而实现了强大的自动化，并实现了这些工具，并实现了这些工具，并实现了这些工具。该筛查设施位于一个丰富的环境中，集中于与疾病生物学和基因组生物学相结合的小分子和小分子筛查。我们在这里提出了一项计划，以在哈佛大学和麻省理工学院（BCSC）开展全面的筛查中心，通过与更广泛的MLPCN研究社区合作，利用和补充现有的组织和基础设施计划。