Diagnostic Ultrasound for Focal Neuropathies

局灶性神经病变的超声诊断

• 批准号: 7860517
• 负责人: Michael Stephen Cartwright
• 金额: $ 13.33万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860517
• 关键词: Affect; Automobile Driving; Award; Basic Science; Biomedical Engineering; Biostatistical Methods; Carpal Tunnel Syndrome; Clinical; Clinical Research; Clinical Trials; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Disease; Electromyography; Epidemiologic Studies; Etiology; Evaluation; Foundations; Goals; Grant; Image; Imagery; Imaging Techniques; Imaging technology; Individual; International; Ischemia; K-Series Research Career Programs; Knowledge; Lead; Lesion; Masks; Medical; Medical Imaging; Mentors; Modality; Modeling; Muscle; Myxoid cyst; Nerve; Nerve Entrapment; Nerve Sheath Tumors; Nerve compression syndrome; Neural Conduction; Neurologist; Neuroma; Neuropathy; Numbness; Outcome; Pain; Pathology; Patient Care; Patients; Peripheral Nerves; Peripheral Nervous System; Peripheral Nervous System Diseases; Principal Investigator; Prospective Studies; Public Health; Randomized Clinical Trials; Recording of previous events; Research; Research Design; Research Personnel; Research Training; Resolution; Schools; Scientific Evaluation; Severities; Site; Solid; Staging; Structure; Testing; Therapeutic; Therapeutic Intervention; Training; Ultrasonography; United States; Validity and Reliability; Vasculitis; Virginia; Walkers; Wrist; cost; design; disability; experience; forest; functional outcomes; improved; median nerve; neuromuscular; novel diagnostics; patient oriented research; skills; tool; tumor

DESCRIPTION (provided by applicant): PROJECT SUMMARY: The candidate, Michael S. Cartwright, MD is a junior neurologist with experience using neuromuscular ultrasound in clinical and research settings. In June 2008 he completed a Clinical Research Training Grant from the MDA, during which he received training in epidemiology, research design and biostatistical methods. This will provide him with a solid foundation on clinical research, but to develop as a translational researcher he requires training in the basic science of medical imaging and experience with longitudinal patient-oriented studies. During the award period, Dr. Cartwright will be mentored by two individuals with complementary experience in medical imaging. Dr. Francis Walker is an international expert in neuromuscular ultrasound, and Dr. Peter Santago is a biomedical engineer with expertise in the basic science of medical imaging. In addition, Dr. Cartwright will take medical imaging graduate level courses at the Virginia Tech-Wake Forest School of Biomedical Engineering. The research plan is designed to highlight the importance of neuromuscular ultrasound in the diagnostic evaluation of individuals with focal neuropathies and to provide Dr. Cartwright with experience organizing and conducting a clinical trial. The first component of the study will demonstrate the validity and reliability of neuromuscular ultrasound. The second component is a double-masked randomized clinical trial to assess the efficacy of diagnostic ultrasound on the functional outcomes of 150 individuals with focal neuropathies. The hypothesis driving the second component of the study is that individuals diagnosed with a focal neuropathy by a combination of electrodiagnostic studies and ultrasound will have a more refined and accurate diagnosis, will be referred for appropriate treatment more often, and will, therefore, have better functional outcomes compared to those evaluated with traditional electrodiagnostic studies alone. RELEVANCE: Focal neuropathies affect more than 300,000 individuals each year in the United States and medical costs exceed $500 million annually. During this career development award, Dr. Cartwright will acquire the knowledge and skills necessary to bring sophisticated neuromuscular imaging technologies from the developmental stage into the realm of patient care, and the research plan will test if diagnostic ultrasound can lead to improved functional outcomes in individuals with focal neuropathies.

描述（由申请人提供）：项目摘要：候选人Michael S. Cartwright，MD是一名初级神经科医生，具有在临床和研究环境中使用神经肌肉超声的经验。2008年6月，他完成了MDA的临床研究培训补助金，在此期间，他接受了流行病学，研究设计和生物统计方法的培训。这将为他提供临床研究的坚实基础，但要发展成为一名翻译研究员，他需要接受医学成像基础科学的培训，并具有纵向以患者为导向的研究经验。在获奖期间，卡特赖特博士将由两名在医学成像方面具有互补经验的人指导。弗朗西斯步行者博士是神经肌肉超声的国际专家，彼得桑塔戈博士是一名生物医学工程师，擅长医学成像的基础科学。此外，卡特赖特博士将在弗吉尼亚理工大学维克森林生物医学工程学院学习医学成像研究生课程。该研究计划旨在强调神经肌肉超声在局灶性神经病变个体诊断评估中的重要性，并为Cartwright博士提供组织和进行临床试验的经验。研究的第一部分将证明神经肌肉超声的有效性和可靠性。第二部分是一项双盲随机临床试验，以评估诊断超声对150名局灶性神经病变患者功能结局的疗效。驱动研究第二部分的假设是，通过电诊断研究和超声相结合诊断为局灶性神经病变的个体将获得更精确和准确的诊断，将更经常地被转诊接受适当的治疗，因此，与单独使用传统电诊断研究评估的患者相比，将获得更好的功能结局。相关性：在美国，局灶性神经病每年影响超过30万人，每年的医疗费用超过5亿美元。在这个职业发展奖期间，卡特赖特博士将获得必要的知识和技能，将复杂的神经肌肉成像技术从发展阶段带入患者护理领域，研究计划将测试诊断超声是否可以改善局灶性神经病患者的功能结果。