Diagnostic Ultrasound for Focal Neuropathies

局灶性神经病变的超声诊断

• 批准号: 8274681
• 负责人: Michael Stephen Cartwright
• 金额: $ 13.42万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8274681
• 关键词: Affect; Automobile Driving; Award; Basic Science; Biomedical Engineering; Biostatistical Methods; Carpal Tunnel Syndrome; Clinical; Clinical Research; Clinical Trials; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Disease; Electromyography; Epidemiologic Studies; Etiology; Evaluation; Foundations; Goals; Grant; Image; Imagery; Imaging Techniques; Imaging technology; Individual; Instruction; International; Ischemia; K-Series Research Career Programs; Knowledge; Lead; Lesion; Masks; Medical; Medical Imaging; Mentors; Modality; Modeling; Muscle; Myxoid cyst; Nerve; Nerve Entrapment; Nerve Sheath Tumors; Nerve compression syndrome; Neural Conduction; Neurologist; Neuroma; Neuropathy; Numbness; Outcome; Pain; Pathology; Patient Care; Patients; Peripheral; Peripheral Nerves; Peripheral Nervous System; Peripheral Nervous System Diseases; Principal Investigator; Prospective Studies; Public Health; Randomized Clinical Trials; Recording of previous events; Research; Research Design; Research Personnel; Research Training; Resolution; Schools; Scientific Evaluation; Severities; Site; Solid; Staging; Structure; Testing; Therapeutic; Therapeutic Intervention; Training; Ultrasonography; United States; Validity and Reliability; Vasculitis; Virginia; Walkers; Wrist; cost; design; disability; experience; forest; functional outcomes; improved; median nerve; neuromuscular; novel diagnostics; patient oriented research; skills; tool; tumor

PROJECT SUMMARY: The candidate, Michael S. Cartwright, MD is a junior neurologist with experience using neuromuscular ultrasound in clinical and research settings. In June 2008 he completed a Clinical Research Training Grant from the MDA, during which he received training in epidemiology, research design, and biostatistical methods. This will provide him with a solid foundation for clinical research, but to develop as a translational researcher he requires training in the basic science of medical imaging and experience with longitudinal patient-oriented studies. During the award period, Dr. Cartwright will be mentored by two individuals with complementary experience in medical imaging. Dr. Francis Walker is an international expert in neuromuscular ultrasound, and Dr. Peter Santago is a biomedical engineer with expertise in the basic science of medical imaging. In addition, Dr. Cartwright will take medical imaging graduate level courses at the Virginia Tech-Wake Forest School of Biomedical Engineering. The research plan is designed to highlight the importance of neuromuscular ultrasound in the diagnostic evaluation of individuals with focal neuropathies and to provide Dr. Cartwright with experience organizing and conducting a clinical trial. The first component of the study will demonstrate the validity and reliability of neuromuscular ultrasound. The second component is a double-masked randomized clinical trial to assess the efficacy of diagnostic ultrasound on the functional outcomes of 150 individuals with focal neuropathies. The hypothesis driving the second component of the study is that individuals diagnosed with a focal neuropathy by a combination of electrodiagnostic studies and ultrasound will have a more refined and accurate diagnosis, will be referred for appropriate treatment more often, and will, therefore, have better functional outcomes compared to those evaluated with traditional electrodiagnostic studies alone. RELEVANCE (See instructions): Focal neuropathies affect more than 300,000 individuals each year in the United States and medical costs exceed $500 million annually. During this career development award, Dr. Cartwright will acquire the knowledge and skills necessary to bring sophisticated neuromuscular imaging technologies from the developmental stage into the realm of patient care, and the research plan will test if diagnostic ultrasound can lead to improved functional outcomes in individuals with focal neuropathies.

项目摘要：候选人 Michael S. Cartwright 医学博士是一位经验丰富的初级神经科医生 在临床和研究环境中使用神经肌肉超声。 2008年6月，他完成了临床 获得 MDA 的研究培训资助，在此期间他接受了流行病学、研究设计、 和生物统计学方法。这将为他的临床研究提供坚实的基础，但要开发 作为一名转化研究员，他需要接受医学影像基础科学和经验方面的培训 以患者为导向的纵向研究。在颁奖期间，卡特赖特博士将受到两位导师的指导 在医学成像方面具有互补经验的个人。弗朗西斯·沃克博士是一位国际专家 Peter Santago 博士拥有神经肌肉超声领域的博士学位，是一位生物医学工程师，拥有基础知识方面的专业知识 医学影像科学。此外，卡特赖特博士还将在以下学校学习医学成像研究生水平课程： 弗吉尼亚理工大学维克森林生物医学工程学院。该研究计划旨在突出 神经肌肉超声在局灶性个体诊断评估中的重要性 神经病，并为卡特赖特博士提供组织和进行临床试验的经验。这 该研究的第一部分将证明神经肌肉超声的有效性和可靠性。这 第二个组成部分是双盲随机临床试验，以评估诊断的有效性 对 150 名局灶性神经病患者的功能结果进行超声检查。驱动的假设 该研究的第二个组成部分是，通过以下组合诊断患有局灶性神经病的个体 电诊断研究和超声波将有更精细和准确的诊断，将被转介给 更频繁地进行适当的治疗，因此与那些治疗相比，会产生更好的功能结果 仅用传统的电诊断研究进行评估。 相关性（参见说明）： 在美国，局灶性神经病每年影响超过 300,000 人并产生医疗费用 每年超过5亿美元。在此职业发展奖期间，卡特赖特博士将获得 引进先进的神经肌肉成像技术所需的知识和技能 进入患者护理领域的发展阶段，该研究计划将测试诊断超声是否 可以改善患有局灶性神经病的个体的功能结果。