Impact of Ghrelin of Beta-cell Function and Insulin Sensitivity in Humans

生长素释放肽对人类 β 细胞功能和胰岛素敏感性的影响

基本信息

  • 批准号:
    7906865
  • 负责人:
  • 金额:
    $ 17.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-25 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This application is to provide protected time in order to perform patient oriented research with the goal of becoming an independent investigator studying the physiological and pharmacological functions of gut hormones and glucose metabolism. Ghrelin, a gut hormone, has been shown to inhibit pancreatic beta-cell insulin secretion and raise plasma glucose levels in humans, but it is unclear whether these are physiologic functions of ghrelin. Importantly, not much is known about the mechanism by which this occurs. The proposed research is designed to test the hypothesis that physiologic levels of ghrelin suppress insulin secretion and stimulate glucagon secretion in healthy human subjects and that this is an action of ghrelin on the islet, rather than one resulting indirectly from alterations in peripheral insulin sensitivity or from changes in counter-regulatory hormones (growth hormone [GH], catecholamines, and cortisol). Specific Aim 1: To determine the dose of ghrelin required to inhibit insulin secretion. Healthy human subjects will receive either ghrelin or saline infusion at three different doses. An intravenous glucose tolerance test will be used to assess insulin secretion. Specific Aim 2: To determine: a) whether ghrelin decreases insulin release by decreasing beta-cell sensitivity to glucose; b) whether ghrelin increases glucagon release by decreasing alpha-cell sensitivity to glucose. Detailed assessments of beta- and alpha-cell functions as well as peripheral insulin sensitivity will be performed using a frequently sampled intravenous glucose tolerance test and an arginine stimulation test in healthy subjects with normal fasting plasma glucose. Specific Aim 3: To measure the relative contribution of the counter-regulatory hormones to the effects of ghrelin on insulin secretion and insulin sensitivity by using either GH receptor blockade, combined beta- and alpha-adrenergic blockade, or infusion of cortisol in healthy subjects with normal fasting plasma glucose. The development of ghrelin agonists and ghrelin antagonists for treating body weight disorders makes understanding the mechanisms for their effects on glucose metabolism of clinical relevance.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jenny Tong其他文献

Jenny Tong的其他文献

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{{ truncateString('Jenny Tong', 18)}}的其他基金

The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes.
生长素释放肽在健康和糖尿病中调节胰岛素分泌的作用。
  • 批准号:
    8625749
  • 财政年份:
    2013
  • 资助金额:
    $ 17.7万
  • 项目类别:
The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes.
生长素释放肽在健康和糖尿病中调节胰岛素分泌的作用。
  • 批准号:
    9213368
  • 财政年份:
    2013
  • 资助金额:
    $ 17.7万
  • 项目类别:
The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes.
生长素释放肽在健康和糖尿病中调节胰岛素分泌的作用。
  • 批准号:
    8420680
  • 财政年份:
    2013
  • 资助金额:
    $ 17.7万
  • 项目类别:
The Impact of Unacylated Ghrelin on Insulin Secretion and Glucose Tolerance in Hu
非酰化生长素释放肽对胡人胰岛素分泌和糖耐量的影响
  • 批准号:
    7963558
  • 财政年份:
    2010
  • 资助金额:
    $ 17.7万
  • 项目类别:
Impact of Unacylated Ghrelin on Insulin Secretion & Glucose Tolerance in Humans
非酰化生长素释放肽对胰岛素分泌的影响
  • 批准号:
    8135027
  • 财政年份:
    2010
  • 资助金额:
    $ 17.7万
  • 项目类别:
Impact of Ghrelin of Beta-cell Function and Insulin Sensitivity in Humans
生长素释放肽对人类 β 细胞功能和胰岛素敏感性的影响
  • 批准号:
    7805248
  • 财政年份:
    2007
  • 资助金额:
    $ 17.7万
  • 项目类别:
Impact of Ghrelin of Beta-cell Function and Insulin Sensitivity in Humans
生长素释放肽对人类 β 细胞功能和胰岛素敏感性的影响
  • 批准号:
    7498950
  • 财政年份:
    2007
  • 资助金额:
    $ 17.7万
  • 项目类别:
Impact of Ghrelin of Beta-cell Function and Insulin Sensitivity in Humans
生长素释放肽对人类 β 细胞功能和胰岛素敏感性的影响
  • 批准号:
    8122349
  • 财政年份:
    2007
  • 资助金额:
    $ 17.7万
  • 项目类别:
Impact of Ghrelin of Beta-cell Function and Insulin Sensitivity in Humans
生长素释放肽对人类 β 细胞功能和胰岛素敏感性的影响
  • 批准号:
    7674731
  • 财政年份:
    2007
  • 资助金额:
    $ 17.7万
  • 项目类别:

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肾上腺素能药物治疗AD疗效的临床前试验
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