Central Pain Processing in Chronic Face Pain:fMRI Study

慢性面部疼痛的中枢疼痛处理：功能磁共振成像研究

基本信息

批准号：
7751850
负责人：
RINSKJE DE LEEUW
金额：
$ 13.5万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-01 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7751850
关键词：
Acute Acute Pain Address Affect Affective Age Age of Onset Anatomy Animals Anterior Anti-Anxiety Agents Anxiety Area Award Awareness Behavioral Biometry Brain Brain imaging Brain region Burn injury Burning Mouth Syndrome Cerebrum Chronic Clinical Cognitive Complex Data Data Analyses Dentistry Diagnosis Distant Doctor of Philosophy Emotional Environment Epidemiology Estrogens Etiology Exhibits Facial Pain Female Female of child bearing age Fibromyalgia Functional Magnetic Resonance Imaging Funding Gonadal Steroid Hormones Head and neck structure Human Hyperalgesia Hypersensitivity Incidence Intervention Investigation Irritable Bowel Syndrome Kentucky Knowledge Life Limbic System Location Magnetic Resonance Imaging Malignant Neoplasms Mandible Masticatory muscles Measures Medial Medicine Menstruation Mentored Patient-Oriented Research Career Development Award Mentors Migraine Modality Monitor Mouth Diseases Musculoskeletal Diseases Musculoskeletal Pain Myalgia Neuraxis Neurobiology Neurons Opioid Oral health Orofacial Pain Outcome Pain Pain Clinics Pain Disorder Pain Research Pain Threshold Pain management Pain-Free Participant Pathology Patients Pattern Perception Peripheral Personal Satisfaction Persons Phase Physiological Processes Play Prefrontal Cortex Prevalence Principal Investigator Process Protocols documentation Psychology Puberty Recurrent pain Reporting Research Research Design Research Personnel Resistance Role Sample Size Scanning Sensory Serum Signal Transduction Site Somatosensory Cortex Spectrum Analysis Stimulus Stress Structure System Temperature Temporomandibular Joint Disorders Testing Thalamic structure Training Training Programs Trigeminal Neuralgia Trigeminal System Trigeminal nerve structure Universities Woman base central pain chronic neuropathic pain chronic pain cingulate cortex cold temperature college design endogenous opioids experience health science research interdisciplinary approach interest male masticatory myalgia mechanical pressure neuroimaging pressure professor programs reproductive response volunteer

项目摘要

This proposal for a K23 "Mentored Patient-Oriented Research Career Development Award" will provide the candidate with five years of continuous funding to gain a broad knowledge in the design and conduct of complex clinical oral health trials. This training will enhance the research environment of the Orofacial Pain Center and mentoring capacity of the University of Kentucky College of Dentistry. The candidate earned a PhD in General Medicine from the University of Groningen and received three years of postgraduate graduate training in Orofacial Pain at the University of Kentucky. This award would allow the candidate to evolve to an independent investigator and would prepare the candidate to successfully mentor MS and PhD candidates in orofacial pain research. The training program consists of two phases: a didactic component emphasizing courses in research design, biostatistics, data analysis and epidemiology, and a research phase involving a neuroimaging investigation of central pain processing in patients with chronic face pain. Three specific aims are proposed in this training application: Specific Aim 1. To assess the presence of pain augmentation in patients with chronic masticatory myofascial pain; Specific Aim 2. To investigate differences in location and extent of activation of brain regions involved in trigeminal pain processing between patients with chronic masticatory muscle pain and pain-free volunteers; and Specific Aim 3. To investigate the influence of estrogen level on cerebral activation in response to an acute experimental pain stimulus in patients with chronic masticatory muscle pain and pain-free volunteers. Dr. Charles Carlson, PhD, Professor, Departments of Psychology and Oral Health Science and research director of the Orofacial Pain Center, and Dr. Don Gash, PhD, Alumni Professor and Chair, Department of Anatomy and Neurobiology, and director of the Magnetic Resonance Imaging and Spectroscopy Center, will mentor the candidate. There is limited information on cerebral activation in response to stimulation of trigeminal structures in healthy pain-free volunteers as well as in chronic face pain patients. The available data support that there are important differences in the cerebral processing of pain in chronic pain patients compared to pain-free subjects. Moreover, the existing data suggest that in chronic pain conditions the medial pain system, the structures associated with the processing of the emotional-affective component of pain, exhibits altered activity. Additionally, there is a lack of information about the influence of estrogen on the central processing of pain. The available data suggest that estrogen may have an inhibitory / anxiolytic effect on the perception of pain, possibly by modulating the endogenous opioid system. Because neuroimaging data on this topic are scarce, and chronic pain conditions are predominant in women of reproductive age, the role of estrogen on pain should be further explored.

这项针对K23“指导患者的研究职业发展奖”的建议将为拥有五年持续资金的候选人，以在设计和行为方面获得广泛的知识复杂的临床口腔健康试验。该培训将增强口面疼痛的研究环境肯塔基大学牙科学院的中心和指导能力。候选人赢得了格罗宁根大学的普通医学博士学位，并获得了三年的研究生肯塔基大学口头疼痛的研究生培训。该奖项将使候选人能够演变成独立的研究者，并准备候选人成功指导MS和博士学位口面疼痛研究中的候选人。培训计划包括两个阶段：教学成分强调研究设计，生物统计学，数据分析和流行病学的课程以及研究涉及对慢性疼痛患者中枢神经疼痛处理的神经成像研究的相位。在本培训应用中提出了三个具体目标：特定目的1。评估疼痛的存在慢性咀嚼性肌筋膜疼痛患者的增强；特定目的2。调查差异在患者之间涉及三叉神经疼痛的大脑区域的位置和激活程度上慢性咀嚼肌肉疼痛和无痛的志愿者；和特定目标3。调查雌激素水平对急性实验疼痛刺激的脑激活的影响患有慢性咀嚼肌肉疼痛和无痛志愿者的患者。查尔斯·卡尔森博士博士，教授心理学和口腔健康科学部门以及口面疼痛中心的研究主任，以及 Don Gash博士，校友教授兼解剖学和神经生物学系主任，董事磁共振成像和光谱中心将指导候选人。有限响应刺激三叉神经结构的脑激活的信息志愿者以及慢性疼痛患者。有重要的数据支持与无疼痛受试者相比，慢性疼痛患者疼痛的脑处理差异。此外，现有数据表明，在慢性疼痛条件下，内侧疼痛系统，结构与疼痛的情绪影响成分的处理相关，表现出改变的活动。此外，缺乏有关雌激素对疼痛中心处理的影响的信息。可用的数据表明，雌激素可能对疼痛感知的抑制 /抗焦虑作用，可能通过调节内源性阿片类药物系统。因为关于此主题的神经影像学数据很少，所以慢性疼痛状况主要在生殖年龄的女性中，雌激素对疼痛的作用应该进一步探索。