Intrinsic Axonal factors in Growth and Regeneration

生长和再生中的内在轴突因素

• 批准号: G0501592/1
• 负责人: James Fawcett
• 金额: $ 116.78万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501592%2F1
• 关键词: Intrinsic; Axonal; factors; Growth; Regeneration

When the brain or spinal cord are damaged nerve fibres are cut. In the case of spinal cord injury this disrupts the connection between the brain and the body via the spinal cord. The result is paralysis and loss of sensation below the level of the injury. In order to bring back function to patients it is necessary to stimulate the cut nerve fibres to regenerate. Regeneration is inhibited by the presence of blocking molecules in the spinal cord, by the scar tissue that forms around the injury site. In addition spinal cord nerve fibres have an intrinsically poor ability to regenerate. Treatments are now available to remove some of the inhibition from scar tissue, but these will only be partly effective if the vigour of regeneration of the nerve fibres remains low. Previous research from the Fawcett and Holt laboratories has identified a new way in which the regenerative vigour of the nerve fibres can be boosted. The grant application investigates ways in which this discovery can be made into a treatment for spinal cord injury.

当大脑或脊髓受损时，神经纤维就会被切断。在脊髓损伤的情况下，这会破坏大脑和身体之间通过脊髓的连接。其结果是瘫痪和失去知觉低于水平的伤害。为了恢复患者的功能，有必要刺激切断的神经纤维再生。再生被脊髓中的阻断分子抑制，被损伤部位周围形成的疤痕组织抑制。此外，脊髓神经纤维具有固有的不良再生能力。现在有一些治疗方法可以消除疤痕组织的一些抑制作用，但如果神经纤维的再生活力仍然很低，这些方法只能部分有效。福塞特和霍尔特实验室之前的研究已经确定了一种增强神经纤维再生活力的新方法。这项拨款申请调查了这一发现可以用于治疗脊髓损伤的方法。