Cell and systems analysis of spatial and episodic memory

我的目标是了解我们是如何发现的，记住事物在哪里，以及日常生活中发生在我们身上的事情。我的目标是通过了解大脑不同部位神经元的活动如何实现这些功能来实现这一点，包括使用计算机来了解神经元如何协同工作，以及涉及单细胞数据的实验、功能神经成像和研究患有特定脑损伤的患者。为了进行现实实验，我将使用虚拟现实的最新进展来提供进行这些操作的受控环境。这一点很重要，原因如下：诊断一种神经疾病并监测其进展通常依赖于能够衡量其对行为的影响。许多神经疾病会影响我们寻找周围事物和记忆的能力，例如阿尔茨海默氏症--最常见的痴呆症。在可能需要进行脑部手术的地方(比如一些顽固性癫痫)，能够使用行为测试和成像技术来辨别雨的哪一部分受到影响也是有用的。在更基本的层面上，了解神经元和神经系统是如何工作的将有助于新药的开发。这种类型的基础研究也可能产生意想不到的连锁反应：有助于相关领域的科学发现，如药理学、计算机科学、工程学。

I aim to understand how we find remember where things are and the things that happen to us in everyday life. I aim to do this by understanding how the actions of neurons in different parts of the brain enable these functions, including using computers to see how neurons can work together as well as experiments involving data from single cells, functional neuroimaging and studying patients with specific brain damage. To perform realistic experiments I will use recent advances in virtual reality to provide controlled situations in which to do these things. This is important for the following reasons.Diagnosing a neurological disease and monitoring its progress often depends on being able to measure its effect on behaviour. Many neurological conditions affect our ability find our way around and to remember things, e.g. Alzheimer‘s disease - the most common form of dementia. Where brain surgery may be required (as in some cases of intractable epilepsy) it is also useful to be able to tell which part rain is affected using behavioural tests, and imaging techniques. At a more basic level, understanding how the neurons and neural systems work will aid the development of new medicines. This type of basic research can also have unforeseen knock-on effects: aiding scientific discoveries in related fields such as pharmacology, computer science, engineering.