Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine

描述（由申请人提供）：该提案展示了弗吉尼亚大学（UVA）为NHLBI/NINDS赞助的心血管医学心胸外科研究网络做出重大贡献的巨大潜力。与我们的联盟机构Inova费尔法克斯医院和Carnova罗阿诺克纪念医院一起，我们的团队每年平均进行3,000例成人心血管外科手术（仅UVA就有800例），这些手术可用于网络协议的招募。研究小组由欧文L博士领导。他是弗吉尼亚大学外科系主任，心胸和血管外科医生。他曾参与多个国家的领导角色，涉及心胸研究和教育。他还获得了NHLBI的长期研究资助。共同首席研究员是Karen C博士。约翰斯顿，一个全国公认的血管认证神经学家与NINDS的资金和专业知识，在临床试验，神经保护和成果的研究。此外，约翰登特博士，一个全国知名的心脏病专家，提供具体的专业知识，超声心动图，因为它适用于心脏瓣膜病。心血管外科，中风神经学/神经学结果和心脏病学的独特组合，以及庞大的城市和农村人口基础，保证了UVA将为心血管医学心胸外科研究网络做出实质性和新颖的贡献。我们的具体目标包括： 具体目标1：描述UVA的经验、专业知识和协作性质，这将大大有助于心血管医学心胸外科研究网络的成功。 具体目标二：在一项II期随机临床试验中，通过重新定位二尖瓣后乳头肌证明瓣下入路治疗缺血性二尖瓣返流的概念证据。 具体目标3：在一项随机、设盲、对照的III期试验中，证明接受大型心脏手术的患者围手术期阿托伐他汀治疗的疗效和安全性。初步数据表明，即使没有动脉粥样硬化，这种干预也会降低心脏手术患者的死亡率和发病率。 (End摘要）

DESCRIPTION (provided by applicant): This proposal demonstrates the great potential of the University of Virginia (UVA) to make major contributions to the NHLBI/NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Together with our consortium institutions, Inova Fairfax Hospital and Carilion Roanoke Memorial Hospital, our team performs an average of 3,000 adult cardiovascular surgical procedures annually (> 800 cases at UVA alone) which would be available for recruitment in Network protocols. The investigative group is led by Dr. Irving L. Kron, a cardiothoracic and vascular surgeon who is Chair of the Department of Surgery at UVA. He has been involved in multiple national leadership roles that relate to cardiothoracic research and education. He also has received long term research funding from NHLBI. The co-principal investigator is Dr. Karen C. Johnston, a nationally recognized vascular certified neurologist with NINDS funding and expertise in clinical trials, neuroprotection and outcomes research. Additionally, Dr. John Dent, a nationally known cardiologist, provides specific expertise in echocardiography as it applies to valvular heart disease. The unique mix of cardiovascular surgery, stroke neurology/neurological outcomes, and cardiology in addition to a large urban and rural population base guarantees that UVA will make substantive and novel contributions to the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Our specific aims include: Specific Aim 1: To describe the experience, expertise and collaborative nature of UVA that will substantially contribute to the success of a Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Specific Aim 2: To demonstrate the proof of concept for a subvalvular approach for ischemic mitral valve regurgitation by repositioning the posterior papillary muscle of the mitral valve in a phase II randomized clinical trial. Specific Aim 3: To demonstrate the efficacy and safety of perioperative Atorvastatin therapy for patients undergoing major cardiac surgery in a randomized, blinded, controlled phase III trial. Preliminary data have suggested that this intervention will reduce mortality and morbidity in cardiac surgical patients even without atherosclerosis. (End of Abstract)