Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine

描述(由申请人提供)：这份提案展示了弗吉尼亚大学(UVA)为NHLBI/NINDS赞助的心血管医学心胸外科研究网络做出重大贡献的巨大潜力。连同我们的联盟机构，Inova Fairfax医院和Carilion Roanoke纪念医院，我们的团队平均每年进行3,000例成人心血管外科手术(仅在UVA就有800例)，这些手术将可在Network协议中招募。调查小组由UVA外科主任、心胸和血管外科医生欧文·L·克伦博士领导。他曾在多个国家担任过与心胸研究和教育相关的领导职务。他还从NHLBI获得了长期研究资金。联合首席研究员是Karen C.Johnston博士，他是一位国家公认的血管认证神经学家，拥有NINDS资金和临床试验、神经保护和结果研究方面的专业知识。此外，约翰·登特博士是一位全国知名的心脏病专家，他在超声心动图方面提供了专门的专业知识，因为它适用于瓣膜心脏病。除了庞大的城市和农村人口基础外，心血管外科、中风神经学/神经预后和心脏病学的独特组合确保了UVA将为心血管医学心胸外科研究网络做出实质性和新颖的贡献。我们的具体目标包括： 具体目标1：描述UVA的经验、专业知识和合作性质，这将大大有助于心血管医学心胸外科研究网络的成功。 具体目的2：在一项II期随机临床试验中，通过重新定位二尖瓣后乳头肌来证明瓣下入路治疗缺血性二尖瓣返流的概念。 具体目标3：在一项随机、双盲、对照的III期试验中，证明围手术期阿托伐他汀治疗心脏大手术患者的有效性和安全性。初步数据表明，即使在没有动脉粥样硬化的情况下，这种干预也将降低心脏手术患者的死亡率和发病率。 (摘要结束)

DESCRIPTION (provided by applicant): This proposal demonstrates the great potential of the University of Virginia (UVA) to make major contributions to the NHLBI/NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Together with our consortium institutions, Inova Fairfax Hospital and Carilion Roanoke Memorial Hospital, our team performs an average of 3,000 adult cardiovascular surgical procedures annually (> 800 cases at UVA alone) which would be available for recruitment in Network protocols. The investigative group is led by Dr. Irving L. Kron, a cardiothoracic and vascular surgeon who is Chair of the Department of Surgery at UVA. He has been involved in multiple national leadership roles that relate to cardiothoracic research and education. He also has received long term research funding from NHLBI. The co-principal investigator is Dr. Karen C. Johnston, a nationally recognized vascular certified neurologist with NINDS funding and expertise in clinical trials, neuroprotection and outcomes research. Additionally, Dr. John Dent, a nationally known cardiologist, provides specific expertise in echocardiography as it applies to valvular heart disease. The unique mix of cardiovascular surgery, stroke neurology/neurological outcomes, and cardiology in addition to a large urban and rural population base guarantees that UVA will make substantive and novel contributions to the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Our specific aims include: Specific Aim 1: To describe the experience, expertise and collaborative nature of UVA that will substantially contribute to the success of a Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Specific Aim 2: To demonstrate the proof of concept for a subvalvular approach for ischemic mitral valve regurgitation by repositioning the posterior papillary muscle of the mitral valve in a phase II randomized clinical trial. Specific Aim 3: To demonstrate the efficacy and safety of perioperative Atorvastatin therapy for patients undergoing major cardiac surgery in a randomized, blinded, controlled phase III trial. Preliminary data have suggested that this intervention will reduce mortality and morbidity in cardiac surgical patients even without atherosclerosis. (End of Abstract)