Structure function analysis of vascular endothelial growth factor receptors in angiogenesis

血管内皮生长因子受体在血管生成中的结构功能分析

• 批准号: G0600270/1
• 负责人: Asif Ahmed
• 金额: $ 37.68万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600270%2F1
• 关键词: Structure; function; analysis; vascular; endothelial

Heart attack or stroke can block blood vessels leading to local tissue damage or even death; there is therefore a need to increase blood flow and promote circulation by making new blood vessels. In contrast, inhibiting blood vessel growth prevents cancer and blindness respectively. The formation of blood vessels (angiogenesis) is complex: They are lined with endothelial cells, which divide and re-arrange themselves into new tube-like vessels. Vascular endothelial growth factor is an essential protein for the blood vessel formation and works by binding to receptors on the endothelial cells. This project will determine how these receptors signal to co-ordinate new vessel formation. Discoveries from this study will provide new insight for the development of novel therapeutic approaches to promote or block the growth of new blood vessels.

心脏病发作或中风会阻塞血管，导致局部组织损伤甚至死亡;因此，需要通过制造新血管来增加血液流动和促进循环。相比之下，抑制血管生长可以分别预防癌症和失明。血管的形成（血管生成）是复杂的：它们内衬内皮细胞，这些细胞分裂并重新排列成新的管状血管。血管内皮生长因子是血管形成的必需蛋白质，通过与内皮细胞上的受体结合发挥作用。该项目将确定这些受体如何发出信号以协调新血管的形成。这项研究的发现将为开发新的治疗方法以促进或阻断新血管的生长提供新的见解。