Angiogenic Biomarkers as Predictive Tests for Early Onset Preeclampsia: A Population-Based Study
血管生成生物标志物作为早发先兆子痫的预测测试:一项基于人群的研究
基本信息
- 批准号:G0601295/2
- 负责人:
- 金额:$ 65.9万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2010
- 资助国家:英国
- 起止时间:2010 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Preeclampsia is the most common of the serious complications of pregnancy. It is caused by a defect in the placenta and is symptomless in the early stages. It is currently only detectable by regular antenatal checks on the mother s blood pressure and urine. In its widest forms, preeclampsia affects about 1 in 10 pregnancies overall and 1 in 50 pregnancies severely. It is potentially life-threatening to mother and baby if allowed to develop and progress undetected. Preeclampsia is curable only by delivery, which puts some babies at risk if they have to be delivered prematurely. Recently, scientists have identified chemicals in the blood that appear to be associated with the onset of preeclampsia. However, it is not known how accurate these ?biomarkers? are at predicting preeclampsia, nor how early in the pregnancy the association can be detected. If the biomarkers could provide a warning that a pregnant woman was highly likely to develop symptoms, then preventative treatment could be given early. Furthermore, if women not at all at risk could be identified, then they could be spared repeated visits to the hospital for blood and urine tests. To determine the accuracy of these biomarkers, samples of blood and urine collected from pregnant women from three European countries will be brought to Birmingham for testing. These samples have been donated at three different time points in the pregnancy, to allow the investigators to determine when the best time to test is. The results from the samples will be anonymously linked to clinical information such as blood pressure to see if the biomarkers appear in women who develop preeclampsia. Statistical analysis of the tests and clinical information will provide doctors and midwives with information about the risk of preeclampsia if a women tests positive or negative for these biomarkers.
子痫前期是妊娠最常见的严重并发症。它是由胎盘缺陷引起的,早期没有任何症状。目前,只有对母亲S进行定期产前检查,血压和尿液才能检测到。在其最广泛的形式中,子痫前期总体上影响约1/10的妊娠,1/50的妊娠受到严重影响。如果任由其发展和发展而不被发现,可能会危及母婴的生命。先兆子痫只能通过分娩来治愈,如果不得不早产,这会使一些婴儿面临风险。最近,科学家们已经发现血液中的化学物质似乎与先兆子痫的发病有关。然而,还不知道这些生物标志物的准确性有多高?他们擅长预测先兆子痫,也不知道在怀孕多早的时候可以检测到这种联系。如果生物标志物可以提供孕妇极有可能出现症状的警告,那么就可以及早给予预防性治疗。此外,如果完全没有风险的妇女能够被识别出来,那么她们就可以避免重复去医院进行血液和尿液测试。为了确定这些生物标志物的准确性,来自三个欧洲国家的孕妇的血液和尿液样本将被带到伯明翰进行检测。这些样本在怀孕期间的三个不同时间点被捐赠,让调查人员能够确定何时是检测的最佳时间。样本的结果将匿名与血压等临床信息联系起来,看看这些生物标记物是否出现在患有先兆子痫的女性身上。对测试和临床信息的统计分析将为医生和助产士提供有关先兆子痫风险的信息,如果女性这些生物标志物检测呈阳性或阴性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Asif Ahmed其他文献
Brief Naturalistic Stressors Cause Shift of TH1 to TH2 Cytokine Response and Increase Disease Susceptibility
短暂的自然应激源导致 TH1 细胞因子反应转变为 TH2 细胞因子反应并增加疾病易感性
- DOI:
- 发表时间:
2008 - 期刊:
- 影响因子:0
- 作者:
Mahbub;N. Haque;A. Islam;U. Salma;Asif Ahmed;I. J. Mukti;A. Haque - 通讯作者:
A. Haque
Subgrade Seasonal Variation Detection through Field Instrumentation in Central New York
通过纽约中部现场仪表检测路基季节性变化
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Asif Ahmed;Md Jobair Bin Alam;S.A.K. Madanayake;Muhasina Manjur Dola;Colin S. Campbell - 通讯作者:
Colin S. Campbell
of angiogenesis and inhibition of leukocytic infiltration Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction
血管生成和白细胞浸润抑制 VEGF 诱导体内血红素加氧酶 1 的双功能作用:诱导
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
O. Haskard;J. Mason;B. Bussolati;Asif Ahmed;H. Pemberton;R. Landis - 通讯作者:
R. Landis
EFFECTS OF CLIMATIC LOADING IN FLEXIBLE PAVEMENT SUBGRADES IN TEXAS
- DOI:
- 发表时间:
2017-12 - 期刊:
- 影响因子:0
- 作者:
Asif Ahmed - 通讯作者:
Asif Ahmed
2 Placental cystathionine-B-synthase impact on fetal growth restriction: Placenta and decidua
- DOI:
10.1016/j.preghy.2016.08.084 - 发表时间:
2016-07-01 - 期刊:
- 影响因子:
- 作者:
Keqing Wang;Ilkay Alp Yildirim;Meng Cai;Shakil Ahmad;Asif Ahmed - 通讯作者:
Asif Ahmed
Asif Ahmed的其他文献
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{{ truncateString('Asif Ahmed', 18)}}的其他基金
I-Corps: A Recycled Plastic Pin for Highway Slope Stability
I-Corps:用于公路边坡稳定性的再生塑料销钉
- 批准号:
2224282 - 财政年份:2022
- 资助金额:
$ 65.9万 - 项目类别:
Standard Grant
A Proof of Principle Randomised Placebo-Controlled Trial for Use of Statins to Ameliorate Early Onset Preeclampsia
使用他汀类药物改善早发性先兆子痫的随机安慰剂对照试验原理证明
- 批准号:
G0701824/2 - 财政年份:2012
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
The Role of Endogenous Vascular Protection Factors in Preeclampsia
内源性血管保护因子在先兆子痫中的作用
- 批准号:
G0700288/3 - 财政年份:2012
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
The Role of Endogenous Vascular Protection Factors in Preeclampsia
内源性血管保护因子在先兆子痫中的作用
- 批准号:
G0700288/2 - 财政年份:2010
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
A Proof of Principle Randomised Placebo-Controlled Trial for Use of Statins to Ameliorate Early Onset Preeclampsia
使用他汀类药物改善早发性先兆子痫的随机安慰剂对照试验原理证明
- 批准号:
G0701824/1 - 财政年份:2010
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
Angiogenic Biomarkers as Predictive Tests for Early Onset Preeclampsia: A Population-Based Study
血管生成生物标志物作为早发先兆子痫的预测测试:一项基于人群的研究
- 批准号:
G0601295/1 - 财政年份:2008
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
The Role of Endogenous Vascular Protection Factors in Preeclampsia
内源性血管保护因子在先兆子痫中的作用
- 批准号:
G0700288/1 - 财政年份:2008
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
Structure function analysis of vascular endothelial growth factor receptors in angiogenesis
血管内皮生长因子受体在血管生成中的结构功能分析
- 批准号:
G0600270/1 - 财政年份:2006
- 资助金额:
$ 65.9万 - 项目类别:
Research Grant
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