Longitudinal Study of Bone Disease and the Impact of Growth Hormone Treatment

骨疾病和生长激素治疗影响的纵向研究

• 批准号: 7884802
• 负责人: Lynda Elizabeth Polgreen
• 金额: $ 6.18万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7884802
• 关键词: Address; Architecture; Biological Markers; Bone Diseases; Child; Computers; Disease; Goals; Growth; Height; Longitudinal Studies; Measurement; Measures; Metabolism; Methods; Minnesota; Neurocognitive; Outcome; Patient Recruitments; Peripheral; Population; Prospective Studies; Research; Serum Markers; Somatotropin; Somatropin; Techniques; Testing; Therapy Clinical Trials; Treatment outcome; Universities; Utah; Work; bone; bone health; bone metabolism; bone turnover; density; tomography

The proposed study is a multi-institutional, 5-year, longitudinal study of bone disease in children with MRS I, II, and VI. The overall goal is to characterize bone disease in MRS I, II, and VI by measurements of bone architecture, density, strength, metabolism, and mobility. This will be done using the techniques of dual energy x-ray absorptiometry (DXA), peripheral quantitative computer tomography (pQCT), and serum markers of bone metabolism. The specific aims are: 1) To characterize the bone health and bone architecture, density, strength, and mobility, and to document the natural progression of bone disease using DXA, peripheral quantitative computer tomography (pQCT), biomarkers of bone turnover, and tests of mobility. 2) In a subset of the population (height < -2 SDS) we aim to assess the efficacy of human growth hormone (hGH) on increasing growth velocity, and the impact on bone health and architecture, mobility, and neurocognitive outcomes during 2 study years. 3) To standardize measurements of DXA, pQCT, and mobility between the University of Minnesota and the University of Utah such that these measures could then be used in other network, multi-center therapeutic trials.

拟议的研究是一项多机构、5年、对多发性硬化I型儿童骨病的纵向研究。