BONE MINERAL RESORPTION IN CHILDREN AFTER HEMATOPOIETIC CELL TRANSPLANTATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的意义在于，所获得的数据将确定骨吸收增加是否有助于造血细胞移植(HCT)后儿童骨密度(BMD)的下降，从而导致骨量减少和骨质疏松。本研究的目的是(1)评估HCT后儿童的骨矿物质吸收，以确定骨吸收增加是否与HCT后发现的骨质疏松症有关；(2)证实HCT后6个月骨密度的下降；(3)将HCT后6个月骨吸收标志物的变化与BMD的变化联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The significance of this study is that the data obtained will determine whether or not increased bone resorption is contributing to the decrease in bone mineral density (BMD) found in children after hematopoietic cell transplantation (HCT) leading to osteopenia and osteoporosis. This study aims to (1) evaluate bone mineral resorption in children following HCT to determine if increased bone mineral resorption contributes to the osteoporosis found in children after HCT, (2) to confirm the decrease in BMD 6 months after HCT, and (3) to correlate changes in the markers of bone resorption with changes in BMD over a period of 6 months following HCT.