BONE MINERAL RESORPTION IN CHILDREN AFTER HEMATOPOIETIC CELL TRANSPLANTATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的意义在于，获得的数据将确定骨吸收增加是否有助于造血细胞移植（HCT）后儿童骨密度（BMD）降低，导致骨质减少和骨质疏松症。 本研究旨在（1）评价HCT后儿童的骨矿物质吸收，以确定骨矿物质吸收增加是否有助于HCT后儿童中发现的骨质疏松症，（2）确认HCT后6个月BMD降低，（3）将骨吸收标志物的变化与HCT后6个月内BMD的变化相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The significance of this study is that the data obtained will determine whether or not increased bone resorption is contributing to the decrease in bone mineral density (BMD) found in children after hematopoietic cell transplantation (HCT) leading to osteopenia and osteoporosis. This study aims to (1) evaluate bone mineral resorption in children following HCT to determine if increased bone mineral resorption contributes to the osteoporosis found in children after HCT, (2) to confirm the decrease in BMD 6 months after HCT, and (3) to correlate changes in the markers of bone resorption with changes in BMD over a period of 6 months following HCT.