CATION AND LIGAND BINDING TO UNUSUAL DNA STRUCTURES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们正在研究阳离子结合的DNA四链体和DNA-配体复合物的细节，确定通过圆二色谱，核磁共振（NMR），以及计算方法。 这些结构的分析需要使用Chimera，MidasPlus和Sparky（都是在RBVI内开发的）以及其他程序。 Chimera还用于帮助可视化结果，并获得否则必须获得的视图和结构比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are investigating the details of cation binding to DNA quadruplexes and DNA-ligand complexes as determined by Circular dichroism, Nuclear Magnetic Resonance (NMR), as well as computational methods. The analysis of these structures requires use of Chimera, MidasPlus, and Sparky, (all developed within the RBVI) as well as other programs. Chimera is also used to help visualize results and obtain otherwise had to obtain views and structural comparisons.