CATION AND LIGAND BINDING TO UNUSUAL DNA STRUCTURES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在研究通过圆二色谱、核磁共振和计算方法确定的阳离子与DNA四链体和DNA配体络合物的结合细节。对这些结构的分析需要使用Chimera、MidasPlus和Sparky(都是在RBVI中开发的)以及其他程序。 Chimera还被用来帮助可视化结果，并获得其他必须获得的视图和结构比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are investigating the details of cation binding to DNA quadruplexes and DNA-ligand complexes as determined by Circular dichroism, Nuclear Magnetic Resonance (NMR), as well as computational methods. The analysis of these structures requires use of Chimera, MidasPlus, and Sparky, (all developed within the RBVI) as well as other programs. Chimera is also used to help visualize results and obtain otherwise had to obtain views and structural comparisons.