DEVELOPMENT OF APPROPRIATE CORONARY HEART DISEASE RISK PREDICTION MODELS

开发适当的冠心病风险预测模型

• 批准号: 7954018
• 负责人: MORRIS SCHAMBELAN
• 金额: $ 0.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954018
• 关键词: Age; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Development; Equation; Funding; Grant; HIV; Highly Active Antiretroviral Therapy; Individual; Institution; Intervention; Life Expectancy; Mass Spectrum Analysis; Modeling; Patients; Persons; Research; Research Personnel; Resources; Risk; Source; United States National Institutes of Health; Virus Diseases; base; biomedical resource; experience; heart disease prevention; heart disease risk; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prediction equations for coronary heart disease (CHD) risk are useful tools that inform clinicians and patients about the absolute risk for developing CHD. A basic principle in CHD prevention is that the intensity of risk-reducing interventions should be based on the individual patient's absolute CHD risk. In the current era of human immunodeficiency virus (HIV) infection and highly active antiretroviral therapy (HAART), knowing one's CHD risk and acting to reduce it have become imperative to long-term survival. Given the increased life expectancy as a result of HAART, more HIV-infected persons will experience complications not related to HIV per se and will reach an age at which they are at increased risk for developing CHD.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 冠心病 (CHD) 风险预测方程是有用的工具，可告知临床医生和患者发生冠心病的绝对风险。 CHD 预防的基本原则是，降低风险干预措施的强度应基于个体患者的绝对 CHD 风险。在当今人类免疫缺陷病毒 (HIV) 感染和高效抗逆转录病毒治疗 (HAART) 的时代，了解自己的冠心病风险并采取行动降低风险已成为长期生存的必要条件。鉴于HAART导致预期寿命延长，更多的HIV感染者将出现与HIV本身无关的并发症，并且将达到患CHD风险增加的年龄。