DEVELOPMENT OF APPROPRIATE CORONARY HEART DISEASE RISK PREDICTION MODELS

开发适当的冠心病风险预测模型

• 批准号: 8168765
• 负责人: MORRIS SCHAMBELAN
• 金额: $ 1.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168765
• 关键词: Age; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Development; Equation; Funding; Grant; HIV; Highly Active Antiretroviral Therapy; Individual; Institution; Intervention; Life Expectancy; Modeling; Patients; Persons; Research; Research Personnel; Resources; Risk; Source; United States National Institutes of Health; Virus Diseases; base; experience; heart disease prevention; heart disease risk; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prediction equations for coronary heart disease (CHD) risk are useful tools that inform clinicians and patients about the absolute risk for developing CHD. A basic principle in CHD prevention is that the intensity of risk-reducing interventions should be based on the individual patient's absolute CHD risk. In the current era of human immunodeficiency virus (HIV) infection and highly active antiretroviral therapy (HAART), knowing one's CHD risk and acting to reduce it have become imperative to long-term survival. Given the increased life expectancy as a result of HAART, more HIV-infected persons will experience complications not related to HIV per se and will reach an age at which they are at increased risk for developing CHD.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 冠心病（CHD）风险预测方程是告知临床医生和患者发生CHD的绝对风险的有用工具。冠心病预防的一个基本原则是，降低风险的干预措施的强度应基于个体患者的绝对冠心病风险。在当前人类免疫缺陷病毒（HIV）感染和高效抗逆转录病毒治疗（HAART）的时代，了解自己的CHD风险并采取行动降低它已成为长期生存的必要条件。由于高效抗逆转录病毒疗法延长了预期寿命，更多的艾滋病毒感染者将出现与艾滋病毒本身无关的并发症，并将达到患冠心病风险增加的年龄。