MODULATION OF THE REGULATORY ACTIVITY OF BACTERIAL TWO-COMPONENT SYSTEMS BY SLY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 转录调节因子SlyA通过PhoP/PhoQ双组分系统的激活控制了影响沙门氏菌毒力的许多因子的细胞内表达。通过使用SILAC分析剖析SlyA调节子，我们发现SlyA增强PhoP激活位点的整体转录。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Activation of transcriptional regulator SlyA by the PhoP/PhoQ two-component system controls intracellular expression of numerous factors influencing Salmonella virulence. By dissecting the SlyA regulon using SILAC analysis, we found that SlyA enhances overall transcription of PhoP-activated loci.